ST8SIA6

ST8SIA6
Identifiers
Aliases	ST8SIA6 , SIA8F, SIAT8F, ST8SIA-VI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SiaVI, SIAT8-F
External IDs	OMIM: 610139 MGI: 2386797 HomoloGene: 17112 GeneCards: ST8SIA6
Gene location (Human)
Chr.	Chromosome 10 (human)
End	17,454,595 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	13,798,875 bp
RNA expression pattern
	Top expressed in
	substantia nigra; ; left ventricle; ; lung; ; thymus; ; monocyte; ; hypothalamus; ; prefrontal cortex; ; upper lobe of left lung; ; spinal cord; ; superior frontal gyrus;
	Top expressed in
	conjunctival fornix; ; substantia nigra; ; Epithelium of stomach; ; hair follicle; ; cornea; ; lacrimal gland; ; ciliary body; ; respiratory epithelium; ; olfactory epithelium; ; kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; sialyltransferase activity ; glycosyltransferase activity ; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ;
Cellular component	integral component of membrane ; Golgi membrane ; Golgi apparatus ; membrane ;
Biological process	glycolipid biosynthetic process ; sialylation ; protein glycosylation ; protein O-linked glycosylation ; glycoprotein metabolic process ; oligosaccharide metabolic process ; ganglioside biosynthetic process ; carbohydrate biosynthetic process ; blastocyst hatching ;
	Sources:Amigo / QuickGO
Orthologs
	338596
	241230
	ENSG00000148488
	ENSMUSG00000003418
	P61647
	Q8K4T1
	NM_001004470 ; NM_001345961
	NM_145838
	NP_001004470 ; NP_001332890
	NP_665837
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 is a protein that in humans is encoded by the ST8SIA6 gene. ^[5]

Function

Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).

Related Research Articles

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.

dCTP pyrophosphatase 1 is an enzyme that in humans is encoded by the DCTPP1 gene.

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA4 gene.

Lactosylceramide alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL5 gene.

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.

Alpha-2,8-sialyltransferase 8B is an enzyme that in humans is encoded by the ST8SIA2 gene.

ST3 beta-galactoside alpha-2,3-sialyltransferase 3, also known as ST3GAL3, is a protein which in humans is encoded by the ST3GAL3 gene.

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D) is a sialyltransferase enzyme that in humans is encoded by the ST6GALNAC4 gene.

Polypeptide N-acetylgalactosaminyltransferase 13 is an enzyme that in humans is encoded by the GALNT13 gene.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene. This enzyme adds a N-Acetylneuraminic acid to an O-linked N-Acetylgalactosamine (GalNAc) on a peptide/proteins with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers Thr over Ser containing GalNAc residues.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 is an enzyme that in humans is encoded by the ST6GALNAC2 gene.

Gap junction delta-2 (GJD2), also known as connexin-36 (Cx36) or gap junction alpha-9 (GJA9), is a protein that in humans is encoded by the GJD2 gene.

Gap junction alpha-10 protein, also known as connexin-62 (Cx62), is a protein that in humans is encoded by the GJA10 gene.

WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene.

ST6 beta-galactoside alpha-2,6-sialyltransferase 2 is a protein that in humans is encoded by the ST6GAL2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148488 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003418 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6" . Retrieved 2017-02-02.

ST8SIA6

Contents

Function

Related Research Articles

References

Further reading