STAB1

Last updated
STAB1
Identifiers
Aliases STAB1 , CLEVER-1, FEEL-1, FELE-1, FEX1, STAB-1, SCARH2, stabilin 1, FEEL1
External IDs OMIM: 608560 MGI: 2178742 HomoloGene: 9035 GeneCards: STAB1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015136

NM_138672

RefSeq (protein)

NP_055951

n/a

Location (UCSC) Chr 3: 52.5 – 52.52 Mb Chr 14: 31.14 – 31.17 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Stabilin-1 is a protein that in humans is encoded by the STAB1 gene. [5] [6] [7]

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [7] STAB1 is also known to interact with the protein chitinase domain-containing protein 1.

Related Research Articles

<span class="mw-page-title-main">CCL20</span> Mammalian protein found in Homo sapiens

Chemokine ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.

<span class="mw-page-title-main">CCL19</span> Mammalian protein found in Homo sapiens

Chemokine ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.

<span class="mw-page-title-main">Angiopoietin 1</span> Protein-coding gene in the species Homo sapiens

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

<span class="mw-page-title-main">G protein-coupled bile acid receptor</span> Protein-coding gene in the species Homo sapiens

The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) as is a protein that in humans is encoded by the GPBAR1 gene.

<span class="mw-page-title-main">OLR1</span> Protein-coding gene in the species Homo sapiens

Oxidized low-density lipoprotein receptor 1 also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene.

<span class="mw-page-title-main">LPAR2</span> Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene. LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">GPR124</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">CCBP2</span> Protein-coding gene in the species Homo sapiens

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.

<span class="mw-page-title-main">MSR1</span> Protein-coding gene in the species Homo sapiens

Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. MSR1 has also been designated CD204.

<span class="mw-page-title-main">SEMA4D</span>

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.

<span class="mw-page-title-main">HAS2</span> Protein-coding gene in the species Homo sapiens

Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene.

<span class="mw-page-title-main">JAM2</span> Protein-coding gene in the species Homo sapiens

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322.

<span class="mw-page-title-main">WASF3</span>

Wiskott–Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.

<span class="mw-page-title-main">HAS1</span> Protein-coding gene in the species Homo sapiens

Hyaluronan synthase 1 is an enzyme that in humans is encoded by the HAS1 gene.

<span class="mw-page-title-main">DNM3</span> Protein-coding gene in the species Homo sapiens

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene. The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding. DNM3 is upregulated in Sézary's syndrome.

<span class="mw-page-title-main">LYVE1</span> Protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis

Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor. In humans it is encoded by the LYVE1 gene.

<span class="mw-page-title-main">TNFSF18</span> Protein-coding gene in the species Homo sapiens

Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene.

<span class="mw-page-title-main">STAB2</span> Protein-coding gene in the species Homo sapiens

Stabilin-2 is a protein that in humans is encoded by the STAB2 gene.

<span class="mw-page-title-main">Fasciclin domain</span>

In molecular biology, the fasciclin domain is an extracellular domain of about 140 amino acid residues. It has been suggested that the FAS1 domain represents an ancient cell adhesion domain common to plants and animals; related FAS1 domains are also found in bacteria.

Liver sinusoidal endothelial cells (LSECs) form the lining of the smallest blood vessels in the liver, also called the hepatic sinusoids. LSECs are highly specialized endothelial cells with characteristic morphology and function. They constitute an important part of the reticuloendothelial system (RES).

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000010327 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042286 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S (Feb 2002). "Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues". Biochem J. 362 (Pt 1): 155–64. doi:10.1042/0264-6021:3620155. PMC   1222372 . PMID   11829752.
  6. Adachi H, Tsujimoto M (Sep 2002). "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities". J Biol Chem. 277 (37): 34264–70. doi: 10.1074/jbc.M204277200 . PMID   12077138.
  7. 1 2 "Entrez Gene: STAB1 stabilin 1".

Further reading