STAMBP

STAMBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XZE, 3RZU, 3RZV
Identifiers
Aliases	STAMBP , AMSH, MICCAP, STAM binding protein
External IDs	OMIM: 606247; MGI: 1917777; HomoloGene: 4719; GeneCards: STAMBP; OMA:STAMBP - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse) [1] Band 6|6 C3 Start 83,520,193 bp [1] End 83,549,711 bp [1]
Gene ontology Molecular function protein domain specific binding metal ion binding peptidase activity protein binding thiol-dependent deubiquitinase hydrolase activity metallopeptidase activity Lys63-specific deubiquitinase activity Cellular component endosome membrane plasma membrane nucleoplasm early endosome cleavage furrow extracellular exosome nucleus cytoplasm cytosol Biological process negative regulation of neuron apoptotic process receptor signaling pathway via JAK-STAT mitotic cytokinesis proteolysis negative regulation of Ras protein signal transduction negative regulation of phosphatidylinositol 3-kinase signaling positive regulation of cell population proliferation protein deubiquitination protein K63-linked deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10617 70527 Ensembl ENSG00000124356 ENSMUSG00000006906 UniProt O95630 Q9CQ26 RefSeq (mRNA) NM_006463 NM_201647 NM_213622 NM_024239 NM_001362078 NM_001362079 NM_001362080 RefSeq (protein) NP_006454 NP_964010 NP_998787 NP_001340896 NP_001340897 NP_001340898 NP_001340899 NP_001340900 NP_001340901 NP_001340902 NP_001340903 NP_001340904 NP_001340905 NP_077201 NP_001349007 NP_001349008 NP_001349009 Location (UCSC) n/a Chr 6: 83.52 – 83.55 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

STAM-binding protein is a protein that in humans is encoded by the STAMBP gene. ^{[4] [5]}

Function

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. ^[5]

Clinical significance

Mutations in this gene have been associated with a unique congenital progressive encephalopathy known as MIC-CAP. ^[6]

Interactions

STAMBP has been shown to interact with RNF11, ^[7] Signal transducing adaptor molecule ^{[4] [8]} and GRAP2. ^{[9] [10]}

References

1. GRCm38: Ensembl release 89: ENSMUSG00000006906 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, et al. (July 1999). "Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines". The Journal of Biological Chemistry. 274 (27): 19129–19135. doi: 10.1074/jbc.274.27.19129 . PMID   10383417.
5. "Entrez Gene: STAMBP STAM binding protein".
6. McDonell LM, Mirzaa GM, Alcantara D, Schwartzentruber J, Carter MT, Lee LJ, et al. (FORGE Canada Consortium) (2013). "Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly–capillary malformation syndrome". Nature Genetics. 45 (5): 556–562. doi: 10.1038/ng.2602 . ISSN   1061-4036. PMC   4000253 . PMID   23542699.
7. Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–1808. doi:10.1038/sj.onc.1207319. PMID   14755250. S2CID   37253372.
8. Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–37487. doi: 10.1074/jbc.M007251200 . PMID   10982817.
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
10. Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, et al. (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of Experimental Medicine. 189 (9): 1383–1390. doi:10.1084/jem.189.9.1383. PMC   2193052 . PMID   10224278.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–358. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, et al. (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of Experimental Medicine. 189 (9): 1383–1390. doi:10.1084/jem.189.9.1383. PMC   2193052 . PMID   10224278.
• Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, et al. (July 2000). "STAM2, a new member of the STAM family, binding to the Janus kinases". FEBS Letters. 477 (1–2): 55–61. Bibcode:2000FEBSL.477...55E. doi:10.1016/S0014-5793(00)01760-9. PMID   10899310. S2CID   31811757.
• Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (August 2001). "Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads". The EMBO Journal. 20 (15): 4132–4142. doi:10.1093/emboj/20.15.4132. PMC   149146 . PMID   11483516.
• Ishii N, Owada Y, Yamada M, Miura S, Murata K, Asao H, et al. (December 2001). "Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice". Molecular and Cellular Biology. 21 (24): 8626–8637. doi:10.1128/MCB.21.24.8626-8637.2001. PMC   100023 . PMID   11713295.
• Maytal-Kivity V, Reis N, Hofmann K, Glickman MH (Sep 2002). "MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function". BMC Biochemistry. 3 28. doi: 10.1186/1471-2091-3-28 . PMC   129983 . PMID   12370088.
• Ibarrola N, Kratchmarova I, Nakajima D, Schiemann WP, Moustakas A, Pandey A, et al. (January 2004). "Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling". BMC Cell Biology. 5 2. doi: 10.1186/1471-2121-5-2 . PMC   385422 . PMID   14728725.
• Ambroggio XI, Rees DC, Deshaies RJ (January 2004). "JAMM: a metalloprotease-like zinc site in the proteasome and signalosome". PLOS Biology. 2 (1): E2. doi: 10.1371/journal.pbio.0020002 . PMC   300881 . PMID   14737182.
• Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–1808. doi:10.1038/sj.onc.1207319. PMID   14755250. S2CID   37253372.
• McCullough J, Clague MJ, Urbé S (August 2004). "AMSH is an endosome-associated ubiquitin isopeptidase". The Journal of Cell Biology. 166 (4): 487–492. doi:10.1083/jcb.200401141. PMC   2172215 . PMID   15314065.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Row PE, Prior IA, McCullough J, Clague MJ, Urbé S (May 2006). "The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation". The Journal of Biological Chemistry. 281 (18): 12618–12624. doi: 10.1074/jbc.M512615200 . PMID   16520378.
• Nakamura M, Tanaka N, Kitamura N, Komada M (June 2006). "Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes". Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 11 (6): 593–606. doi:10.1111/j.1365-2443.2006.00963.x. PMID   16716190. S2CID   30077507.
• Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (September 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–346. doi:10.1016/j.ygeno.2006.04.003. PMID   16730941.