STARD10 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | STARD10 , NY-CO-28, PCTP2, SDCCAG28, CGI-52, StAR related lipid transfer domain containing 10 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 617382 MGI: 1860093 HomoloGene: 4841 GeneCards: STARD10 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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StAR-related lipid transfer protein 10 (STARD10) or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene. [5] [6] The protein derives its name from the fact that the molecule contains a START domain. As part of the StarD2 subfamily, StarD10 can transport the lipids phosphatidylcholine and phosphatidylethanolamine between membranes in solution. [7] Casein kinase II phosphorylates the protein on its serine at position 184. [8]
The function of StarD10 in the cell is not yet understood. Its expression is associated with cancer, but the nature of its role is unclear. Most recent data indicate that loss of StarD10 expression in breast cancer is associated with poor outcomes in patients. [9]
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 or CD340.
Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene.
Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.
Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene.
Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene.
AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage as part of the insulin signal transduction pathway.
Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene.
Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. STAT5A orthologs have been identified in several placentals for which complete genome data are available.
Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.
RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.
In enzymology, an elongation factor 2 kinase is an enzyme that catalyzes the chemical reaction:
Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.
Serine/threonine-protein kinase N2 is an enzyme that in humans and Strongylocentrotus purpuratus is encoded by the PKN2 gene.
Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.
Serine-threonine kinase receptor-associated protein is an enzyme that in humans is encoded by the STRAP gene.
Collagen type IV alpha-3-binding protein, also known as ceramide transfer protein (CERT) or StAR-related lipid transfer protein 11 (STARD11) is a protein that in humans is encoded by the COL4A3BP gene. The protein contains a pleckstrin homology domain at its amino terminus and a START domain towards the end of the molecule. It is a member of the StarD2 subfamily of START domain proteins.
Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.
LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.
Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.
The human gene AGK encodes the enzyme mitochondrial acylglycerol kinase.