STARD13

STARD13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H80, 2JW2, 2PSO
Identifiers
Aliases	STARD13 , ARHGAP37, DLC2, GT650, LINC00464, StAR related lipid transfer domain containing 13
External IDs	OMIM: 609866; MGI: 2385331; HomoloGene: 64844; GeneCards: STARD13; OMA:STARD13 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q13.1-q13.2 Start 33,103,137 bp [1] End 33,350,630 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G3 Start 150,960,975 bp [2] End 151,157,301 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve muscle layer of sigmoid colon epithelium of colon spinal ganglia trigeminal ganglion right lung thyroid gland left lobe of thyroid gland right lobe of thyroid gland Achilles tendon Top expressed in zygote secondary oocyte lumbar spinal ganglion vestibular membrane of cochlear duct primary oocyte retinal pigment epithelium sciatic nerve left lung lobe right lung lobe saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding GTPase activator activity Cellular component cytoplasm cytosol lipid droplet mitochondrial membranes mitochondrion membrane Biological process negative regulation of cell migration involved in sprouting angiogenesis positive regulation of GTPase activity endothelial tube lumen extension regulation of small GTPase mediated signal transduction endothelial cell migration signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90627 243362 Ensembl ENSG00000133121 ENSMUSG00000016128 UniProt Q9Y3M8 Q923Q2 RefSeq (mRNA) NM_001243466 NM_001243474 NM_001243476 NM_052851 NM_178006 NM_178007 NM_178008 NM_001163493 NM_146258 NM_001359985 RefSeq (protein) NP_001230395 NP_001230403 NP_001230405 NP_443083 NP_821074 NP_821075 NP_001156965 NP_666370 NP_001346914 Location (UCSC) Chr 13: 33.1 – 33.35 Mb Chr 5: 150.96 – 151.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins. ^{[5] [6]}

Function and structure

STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases. ^[7] It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly. ^[7]

The protein consists of an N-terminal sterile alpha motif (SAM) domain, ^[8] a serine-rich domain, a RhoGAP domain and at the C-terminus, a StAR-related lipid-transfer domain (START).

Tissue distribution and pathology

The protein was identified in part through its differential expression in cancers. A low level of STARD13 was observed in less differentiated hepatocellular carcinoma tissue with higher RhoA expression. A small patient study finds that the absence of STARD13 in hepatocellular carcinomas correlates with higher levels of RhoA and a poorer prognosis than patients with carcinomas that were STARD13-positive. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000133121 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000016128 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Couch FJ, Rommens JM, Neuhausen SL, Bélanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J (August 1996). "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics. 36 (1): 86–99. doi: 10.1006/geno.1996.0428 . PMID   8812419.
6. "Entrez Gene: STARD13 START domain containing 13".
7. Ching YP, Wong CM, Chan SF, Leung TH, Ng DC, Jin DY, Ng IO (March 2003). "Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma". The Journal of Biological Chemistry. 278 (12): 10824–30. doi: 10.1074/jbc.M208310200 . PMID   12531887.
8. Li, Hongyan; Fung, King-Leung; Jin, Dong-Yan; Chung, Stephen S. M.; Ching, Yick-Pang; Ng, Irene Oi-lin; Sze, Kong-Hung; Ko, Ben C. B.; Sun, Hongzhe (2007-06-01). "Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2". Proteins. 67 (4): 1154–1166. doi:10.1002/prot.21361. ISSN   1097-0134. PMID   17380510. S2CID   20407564.
9. Xiaorong L, Wei W, Liyuan Q, Kaiyan Y (2008). "Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma". BMC Cancer. 8 205. doi: 10.1186/1471-2407-8-205 . PMC   2496915 . PMID   18651974.

Further reading

• Ching YP, Wong CM, Chan SF, Leung TH, Ng DC, Jin DY, Ng IO (March 2003). "Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma". The Journal of Biological Chemistry. 278 (12): 10824–30. doi: 10.1074/jbc.M208310200 . PMID   12531887.
• Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". The Biochemical Journal. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC   1223895 . PMID   14561217.
• Nagaraja GM, Kandpal RP (January 2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochemical and Biophysical Research Communications. 313 (3): 654–65. Bibcode:2004BBRC..313..654N. doi:10.1016/j.bbrc.2003.12.001. PMID   14697242.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY, Ng IO (October 2005). "Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15207–12. Bibcode:2005PNAS..10215207L. doi: 10.1073/pnas.0504501102 . PMC   1250229 . PMID   16217026.