STEAP1

Last updated
STEAP1
Identifiers
Aliases STEAP1 , PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1
External IDs OMIM: 604415 MGI: 1917608 HomoloGene: 8256 GeneCards: STEAP1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012449

NM_027399

RefSeq (protein)

NP_036581

NP_081675

Location (UCSC) Chr 7: 90.15 – 90.16 Mb Chr 5: 5.79 – 5.8 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. [5]

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [5]

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YedZ of E. coli has been examined topologically and has 6 transmembrane segments (TMSs) with both the N- and C-termini localized to the cytoplasm. von Rozycki et al. 2004 identified homologues of YedZ in bacteria and animals. YedZ homologues exhibit conserved histidyl residues in their transmembrane domains that may function in heme binding. Some of the homologues encoded in the genomes of various bacteria have YedZ domains fused to transport, electron transfer and biogenesis proteins. One of the animal homologues is the 6 TMS epithelial plasma membrane antigen of the prostate (STAMP1) that is over-expressed in prostate cancer. Some animal homologues have YedZ domains fused C-terminal to homologues of NADP oxidoreductases.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164647 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015652 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1".

Further reading