STEAP1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | STEAP1 , PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 604415 MGI: 1917608 HomoloGene: 8256 GeneCards: STEAP1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. [5]
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [5]
Sialomucin core protein 24 also known as endolyn or CD164 is a protein that in humans is encoded by the CD164 gene. CD164 functions as a cell adhesion molecule.
C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene.
Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.
Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.
CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene. It is also called CD166, MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.
Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.
Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene. BCAM has also recently been designated CD239.
Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.
ETS homologous factor is a protein that in humans is encoded by the EHF gene. This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.
Tubulointerstitial nephritis antigen-like is a protein that in humans is encoded by the TINAGL1 gene.
Mucin-like protein 1 is a protein that in humans is encoded by the MUCL1 gene.
Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene.
Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.
Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.
Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2 gene.
Protein-glutamine gamma-glutamyltransferase 4 is an enzyme that in humans is encoded by the TGM4 gene.
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.
Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.
STEAP family member 4 is a protein that in humans is encoded by the STEAP4 gene.
YedZ of E. coli has been examined topologically and has 6 transmembrane segments (TMSs) with both the N- and C-termini localized to the cytoplasm. von Rozycki et al. 2004 identified homologues of YedZ in bacteria and animals. YedZ homologues exhibit conserved histidyl residues in their transmembrane domains that may function in heme binding. Some of the homologues encoded in the genomes of various bacteria have YedZ domains fused to transport, electron transfer and biogenesis proteins. One of the animal homologues is the 6 TMS epithelial plasma membrane antigen of the prostate (STAMP1) that is over-expressed in prostate cancer. Some animal homologues have YedZ domains fused C-terminal to homologues of NADP oxidoreductases.