STK17A

STK17A
Identifiers
Aliases	STK17A , DRAK1, serine/threonine kinase 17a
External IDs	OMIM: 604726 HomoloGene: 55846 GeneCards: STK17A
Gene location (Human)
Chr.	Chromosome 7 (human)
End	43,650,713 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; blood; ; bone marrow; ; ganglionic eminence; ; vena cava; ; Achilles tendon; ; spleen; ; islet of Langerhans; ; bone marrow cells;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity ; transferase activity ; nucleotide binding ; protein kinase activity ; protein serine/threonine kinase activity ; ATP binding ;
Cellular component	nucleus ; plasma membrane ; nuclear speck ;
Biological process	positive regulation of apoptotic process ; positive regulation of fibroblast apoptotic process ; protein phosphorylation ; intracellular signal transduction ; regulation of reactive oxygen species metabolic process ; phosphorylation ; apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	9263
	n/a
	ENSG00000164543
	n/a
	Q9UEE5
	n/a
	NM_004760
	n/a
	NP_004751
	n/a
	Wikidata
View/Edit Human

Last updated March 04, 2023

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.^[3]

Function

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.^[3]

In a recent study the gene (among others) shows a major role in centenarians longer lifespan.^[4]

Related Research Articles

Protein kinase C delta type is an enzyme that in humans is encoded by the PRKCD gene.

Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene.

Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene.

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome 17 (17q23.3).

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.

Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.

Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.

TBK1 is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is encoded by the TBK1 gene in humans. This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Insufficient regulation of TBK1 activity leads to autoimmune, neurodegenerative diseases or tumorigenesis.

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.

Homeodomain-interacting protein kinase 3 is an enzyme that in humans is encoded by the HIPK3 gene.

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that is encoded by the RIPK3 gene in humans.

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.

Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the STK24 gene located in the chromosome 13, band q32.2. It is also known as Mammalian STE20-like protein kinase 3 (MST-3). The protein is 443 amino acids long and its mass is 49 kDa.

Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164543 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Serine/threonine kinase 17a".
↑ Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, et al. (May 2021). Tyler JK, Suh Y, Shuldiner AR (eds.). "Whole-genome sequencing analysis of semi-supercentenarians". eLife. 10: e57849. doi: 10.7554/eLife.57849 . PMC 8096429 . PMID 33941312.

Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, et al. (September 2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLOS Genetics. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793 . PMID 19730683.
Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry. 273 (44): 29066–71. doi: 10.1074/jbc.273.44.29066 . PMID 9786912.
Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, et al. (June 2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". The Journal of Biological Chemistry. 286 (22): 19381–91. doi: 10.1074/jbc.M111.218040 . PMC 3103316 . PMID 21489989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164543 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "Entrez Gene: Serine/threonine kinase 17a".

[4] Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, et al. (May 2021). Tyler JK, Suh Y, Shuldiner AR (eds.). "Whole-genome sequencing analysis of semi-supercentenarians". eLife. 10: e57849. doi: 10.7554/eLife.57849 . PMC 8096429 . PMID 33941312.

[1]

[2]

[3]

[4]

STK17A

Contents

Function

Related Research Articles

References

Further reading