STK35L1

Last updated
STK35
Identifiers
Aliases STK35 , serine/threonine kinase 35, CLIK1, STK35L1, Serine/threonine kinase 35
External IDs OMIM: 609370 MGI: 1914583 HomoloGene: 15441 GeneCards: STK35
Orthologs
SpeciesHumanMouse
Entrez

140901

67333

Ensembl

ENSG00000125834

ENSMUSG00000037885

UniProt

Q8TDR2

Q80ZW0

RefSeq (mRNA)

NM_080836

NM_001038635
NM_183262

RefSeq (protein)

NP_543026

NP_001033724
NP_899085

Location (UCSC) Chr 20: 2.1 – 2.18 Mb Chr 2: 129.64 – 129.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene. [5] It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome. Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells. [6] [7] Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1.

Contents

Functions

STK35L1 is predominantly found in the nucleus and the nucleolus. Nuclear actin was identified as a novel binding partner of STK35L1. [8] However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition. Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125834 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037885 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: Serine/threonine kinase 35" . Retrieved 2012-02-18.
  6. ↑ Vallenius T, Mäkelä TP (May 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. doi:10.1242/jcs.115.10.2067. PMID   11973348.
  7. ↑ Goyal P, Behring A, Kumar A, Siess W (2009-09-16). "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLOS ONE. 4 (9): e6981. Bibcode:2009PLoSO...4.6981G. doi: 10.1371/journal.pone.0006981 . PMC   2737284 . PMID   19756140.
  8. ↑ Goyal P, Behring A, Kumar A, Siess W (2011-01-20). "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLOS ONE. 6 (1): e16249. Bibcode:2011PLoSO...616249G. doi: 10.1371/journal.pone.0016249 . PMC   3024402 . PMID   21283756.

Further reading


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