STMN3

STMN3
Identifiers
Aliases	STMN3 , SCLIP, stathmin 3
External IDs	OMIM: 608362 MGI: 1277137 HomoloGene: 7528 GeneCards: STMN3
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	180,956,293 bp
RNA expression pattern
	Top expressed in
	pons; ; middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; superior vestibular nucleus; ; nucleus accumbens; ; entorhinal cortex; ; parietal lobe; ; cerebellar vermis; ; postcentral gyrus;
	Top expressed in
	facial motor nucleus; ; motor neuron; ; barrel cortex; ; superior cervical ganglion; ; pontine nuclei; ; anterior horn of spinal cord; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; prefrontal cortex; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein domain specific binding ; tubulin binding ;
Cellular component	growth cone ; axon ; neuron projection ; Golgi apparatus ; cell projection ; cytoplasm ; cytosol ;
Biological process	microtubule depolymerization ; nervous system development ; regulation of microtubule polymerization or depolymerization ; regulation of GTPase activity ; cytoplasmic microtubule organization ; neuron projection development ; regulation of cytoskeleton organization ; negative regulation of Rac protein signal transduction ; blastocyst hatching ;
	Sources:Amigo / QuickGO
Orthologs
	50861
	20262
	n/a
	ENSMUSG00000027581
	Q9NZ72
	O70166
	NM_001276310 ; NM_015894
	NM_009133
	NP_001263239 ; NP_056978
	NP_033159
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 13, 2024

Stathmin-3 is a protein that in humans is encoded by the STMN3 gene.^[4]^[5]^[6]

Function

The protein encoded by this gene belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. It is similar to the SCG10 protein and is involved in signal transduction and regulation of microtubule dynamics.^[6]

Interactions

STMN3 has been shown to interact with TRPC5.^[7]

Related Research Articles

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is mostly associated with, but not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (γδ) Τ cells and activated CD8+ T cells, as well as on dendritic cells. NCAM has been implicated as having a role in cell–cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory.

Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene.

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.

Growth Associated Protein 43 (GAP43) is a protein encoded by the GAP43 gene in humans.

Transient receptor potential canonical 1 (TRPC1) is a protein that in humans is encoded by the TRPC1 gene.

The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene. TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.

Opsin-3 also known as encephalopsin or panopsin is a protein that, in humans, is encoded by the OPN3 gene. Alternative splicing of this gene results in multiple transcript variants encoding different protein isoforms.

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.

Stathmin-2 is a protein that in humans is encoded by the STMN2 gene.

Septin-6 is a protein that in humans is encoded by the SEPT6 gene.

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.

Dedicator of cytokinesis protein (Dock7) is a large protein encoded in the human by the DOCK7 gene, involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G-proteins. Dock7 activates isoforms of the small G protein Rac.

Microtubule-associated protein 1S is a protein that in humans is encoded by the MAP1S gene.

U2AF homology motif (UHM) kinase 1, also known as UHMK1, is a protein which in humans is encoded by the UHMK1 gene.

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene. Its function appears two be twofold: CEP164 is required for primary cilium formation. Furthermore, it is an important component in the response to DNA damage by UV light.

Centrosomal protein of 76 kDa, also known as CEP76, is a protein that in humans is encoded by the CEP76 gene.

Centrosomal protein of 78 kDa, also known as Cep78, is a protein that in humans is encoded by the CEP78 gene.

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene. It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027581 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ozon S, Byk T, Sobel A (June 1998). "SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system". Journal of Neurochemistry. 70 (6): 2386–96. doi:10.1046/j.1471-4159.1998.70062386.x. PMID 9603203. S2CID 1252160.
↑ Bai C, Connolly B, Metzker ML, Hilliard CA, Liu X, Sandig V, Soderman A, Galloway SM, Liu Q, Austin CP, Caskey CT (February 2000). "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster". Proceedings of the National Academy of Sciences of the United States of America. 97 (3): 1230–5. Bibcode:2000PNAS...97.1230B. doi: 10.1073/pnas.97.3.1230 . PMC 15578 . PMID 10655513.
1 2 "Entrez Gene: STMN3 stathmin-like 3".
↑ Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nature Neuroscience. 6 (8): 837–45. doi:10.1038/nn1092. PMID 12858178. S2CID 7523946.

STMN3

Contents

Function

Interactions

Related Research Articles

References

Further reading