SUGT1

SUGT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RL1
Identifiers
Aliases	SUGT1 , SGT1, SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
External IDs	OMIM: 604098; MGI: 1915205; HomoloGene: 4877; GeneCards: SUGT1; OMA:SUGT1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.3 Start 52,652,709 bp [1] End 52,700,909 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D3 Start 79,825,131 bp [2] End 79,872,636 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium pancreatic epithelial cell myocardium of left ventricle oocyte cartilage tissue parietal pleura tibia pancreatic ductal cell gingival epithelium tendon of biceps brachii Top expressed in morula morula blastocyst otic vesicle medial ganglionic eminence abdominal wall epiblast superior surface of tongue otic placode spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm cytosol nucleus kinetochore ubiquitin ligase complex protein-containing complex Biological process regulation of protein stability mitotic cell cycle protein stabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10910 67955 Ensembl ENSG00000165416 ENSMUSG00000022024 UniProt Q9Y2Z0 Q9CX34 RefSeq (mRNA) NM_001130912 NM_006704 NM_001320831 NM_026474 RefSeq (protein) NP_001124384 NP_001307760 NP_006695 NP_080750 Location (UCSC) Chr 13: 52.65 – 52.7 Mb Chr 14: 79.83 – 79.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene. ^{[5] [6]}

Function

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. ^[6]

Interactions

SUGT1 has been shown to interact with S100A6. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000165416 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022024 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (July 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Molecular Cell. 4 (1): 21–33. doi: 10.1016/S1097-2765(00)80184-7 . PMID   10445024.
6. "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".
7. Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi: 10.1074/jbc.M211518200 . PMID   12746458.

Further reading

• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi: 10.1074/jbc.M211518200 . PMID   12746458.
• Niikura Y, Kitagawa K (December 2003). "Identification of a novel splice variant: human SGT1B (SUGT1B)". DNA Sequence. 14 (6): 436–41. doi:10.1080/10425170310001623644. PMID   15018354. S2CID   20578581.
• Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, Jin F, Gu S, Ying K, Xie Y, Mao Y (April 2004). "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1". DNA Sequence. 15 (2): 140–3. doi:10.1080/1042517032000160215. PMID   15346769. S2CID   37324928.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• da Silva Correia J, Miranda Y, Leonard N, Ulevitch R (April 2007). "SGT1 is essential for Nod1 activation". Proceedings of the National Academy of Sciences of the United States of America. 104 (16): 6764–9. Bibcode:2007PNAS..104.6764D. doi: 10.1073/pnas.0610926104 . PMC   1871859 . PMID   17420470.
• Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A (June 2007). "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6". Biochemical and Biophysical Research Communications. 357 (4): 1148–53. doi:10.1016/j.bbrc.2007.04.073. PMID   17466273.