SYAP1

SYAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X3A
Identifiers
Aliases	SYAP1 , PRO3113, synapse associated protein 1, BSTA
External IDs	MGI: 1914293 HomoloGene: 12078 GeneCards: SYAP1
Gene location (Human) Chr. X chromosome (human) [1] Band Xp22.2 Start 16,719,612 bp [1] End 16,765,340 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X F4 Start 161,640,053 bp [2] End 161,671,443 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon jejunal mucosa tibialis anterior muscle deltoid muscle bronchial epithelial cell gums cavity of mouth duodenum vastus lateralis muscle sperm Top expressed in white adipose tissue brown adipose tissue subcutaneous adipose tissue submandibular gland pineal gland calvaria ovary parotid gland mammary gland utricle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component Golgi apparatus nucleus nucleoplasm extracellular exosome cytosol cytoplasm plasma membrane membrane cell junction axon dendrite growth cone extrinsic component of cytoplasmic side of plasma membrane presynaptic membrane cell projection perikaryon synapse postsynaptic membrane perinuclear region of cytoplasm Biological process cell differentiation cellular response to insulin stimulus cellular response to platelet-derived growth factor stimulus TORC2 signaling positive regulation of fat cell differentiation cellular response to epidermal growth factor stimulus positive regulation of protein serine/threonine kinase activity positive regulation of protein homodimerization activity cellular response to insulin-like growth factor stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94056 67043 Ensembl ENSG00000169895 ENSMUSG00000031357 UniProt Q96A49 Q9D5V6 RefSeq (mRNA) NM_032796 NM_025932 RefSeq (protein) NP_116185 NP_080208 Location (UCSC) Chr X: 16.72 – 16.77 Mb Chr X: 161.64 – 161.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Synapse-associated protein 1 is a protein that in humans is encoded by the SYAP1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000169895 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031357 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, Xing G, Dong C, Zhai Y, Wan J, Ouyang S, Li L, Zhang S, Zhou K, Zhang Y, Wu C, He F (August 2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Research. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC   311073 . PMID   11483580.
6. "Entrez Gene: SYAP1 synapse associated protein 1, SAP47 homolog (Drosophila)".

Further reading

• Yao Y, Suraokar M, Darnay BG, Hollier BG, Shaiken TE, Asano T, Chen CH, Chang BH, Lu Y, Mills GB, Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA (January 2013). "BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation". Science Signaling. 6 (257): ra2. doi:10.1126/scisignal.2003295. PMC   3748614 . PMID   23300339.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Chang YC, Yu YL, Wang N, Xu YH (December 2001). "[Cloning and characterization of syap1, a down regulated gene in human hepatocellular carcinoma]". Shi Yan Sheng Wu Xue Bao. 34 (4): 319–22. PMID   12549212.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.