SYNPR

SYNPR
Identifiers
Aliases	SYNPR , SPO, synaptoporin
External IDs	MGI: 1919253; HomoloGene: 11407; GeneCards: SYNPR; OMA:SYNPR - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p14.2 Start 63,228,315 bp [1] End 63,616,924 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A1 Start 8,853,423 bp [2] End 9,184,983 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus cerebellar vermis nucleus accumbens external globus pallidus Brodmann area 46 middle temporal gyrus caudate nucleus cerebellar hemisphere superior frontal gyrus Brodmann area 23 Top expressed in habenula olfactory tubercle dorsomedial hypothalamic nucleus dentate gyrus nucleus accumbens globus pallidus dentate gyrus of hippocampal formation granule cell suprachiasmatic nucleus lobe of cerebellum neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding syntaxin-1 binding Cellular component synapse membrane cell junction cytoplasmic vesicle integral component of synaptic vesicle membrane synaptic vesicle membrane neuron projection integral component of membrane synaptic vesicle Biological process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 132204 72003 Ensembl ENSG00000163630 ENSMUSG00000056296 UniProt Q8TBG9 Q8BGN8 RefSeq (mRNA) NM_001130003 NM_144642 NM_001163032 NM_028052 RefSeq (protein) NP_001123475 NP_653243 NP_001156504 NP_082328 Location (UCSC) Chr 3: 63.23 – 63.62 Mb Chr 14: 8.85 – 9.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Synaptoporin is a protein that in humans is encoded by the SYNPR gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000163630 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056296 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Leube RE (Aug 1994). "Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human". Differentiation. 56 (3): 163–71. doi:10.1046/j.1432-0436.1994.5630163.x. PMID   8034131.
6. Dai J, Ji C, Gu S, Wu Q, Wang L, Xu J, Zeng L, Ye X, Yin G, Xie Y, Mao Y (Sep 2003). "Cloning and sequence analysis of the human cDNA encoding the synaptoporin (delta), a highly conservative synaptic vesicle protein". Mol Biol Rep. 30 (3): 185–91. doi:10.1023/A:1024907723000. PMID   12974474. S2CID   40874195.
7. "Entrez Gene: SYNPR synaptoporin".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Singec I, Knoth R, Ditter M, et al. (2002). "Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons". J. Comp. Neurol. 452 (2): 139–53. doi:10.1002/cne.10371. PMID   12271488. S2CID   30492933.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tran MH, Yamada K, Nakajima A, et al. (2004). "Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction". Mol. Psychiatry. 8 (4): 407–12. doi:10.1038/sj.mp.4001240. PMID   12740598. S2CID   23487661.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.