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The Sagan River is a seasonal river in southern Ethiopia.
Rising in the Ethiopian Highlands mountains east of Lake Chamo, it flows south then west to join the Weito River at 5°13′N37°1′E / 5.217°N 37.017°E .
It defines part of the boundary between the Southern Nations, Nationalities, and Peoples' Region and the Oromia Region.
Tributaries of the Sagan include the Talpeena [ citation needed ].
In 2023, cholera was traced to the river, with confirmed cases identified to human consumption of river water. [1] At the time, the cholera outbreak in the country was the longest in the country's history to date. [1]