Sebox homeobox

SEBOX
Identifiers
Aliases	SEBOX , OG-9, OG9, OG9X, Sebox homeobox
External IDs	OMIM: 610975; MGI: 108012; HomoloGene: 32052; GeneCards: SEBOX; OMA:SEBOX - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,365,199 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,395,907 bp
RNA expression pattern
	Top expressed in
	testicle; ; right lobe of liver; ; granulocyte; ; skeletal muscle tissue; ; blood; ; monocyte; ; duodenum; ; left adrenal cortex; ; right adrenal gland; ; prefrontal cortex;
	Top expressed in
	zygote; ; gastrula; ; secondary oocyte; ; neural layer of retina; ; primary oocyte; ; CA3 field; ; morula; ; granular layer of epidermis; ; Region II of hippocampus proper; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ; molecular function ;
Cellular component	nucleus ; cellular component ;
Biological process	multicellular organism development ; cell differentiation ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; biological process ; embryo development ending in birth or egg hatching ; oogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	645832
	18292
	ENSG00000274529
	ENSMUSG00000001103
	Q9HB31
	P70368
	NM_001083896 ; NM_001080837
	NM_008759
	NP_001074306
	NP_032785
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 04, 2025

SEBOX homeobox is a protein that in humans is encoded by the SEBOX gene.^[5] Sebox homeobox has a 92% similarity to genes found within rhesus macaque, or the rhesus monkey. It is thought that this is what causes the reddened glutius maximus coloring.

Function

Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000274529 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001103 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SEBOX homeobox". Archived from the original on 2016-04-08. Retrieved 2017-09-11.
↑ Cinquanta M, Rovescalli AC, Kozak CA, Nirenberg M (2000). "Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8904–9. Bibcode:2000PNAS...97.8904C. doi: 10.1073/pnas.97.16.8904 . PMC 16794 . PMID 10922053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000274529 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001103 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SEBOX homeobox". Archived from the original on 2016-04-08. Retrieved 2017-09-11.

[pmid10922053-6] Cinquanta M, Rovescalli AC, Kozak CA, Nirenberg M (2000). "Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8904–9. Bibcode:2000PNAS...97.8904C. doi: 10.1073/pnas.97.16.8904 . PMC 16794 . PMID 10922053.

[1]

[2]

[3]

[4]

[5]

[6]