Selenophosphate synthetase 1

SEPHS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FD5, 3FD6
Identifiers
Aliases	SEPHS1 , SELD, SPS, SPS1, Selenophosphate synthetase 1
External IDs	OMIM: 600902 MGI: 1923580 HomoloGene: 56558 GeneCards: SEPHS1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10p13 Start 13,317,428 bp [1] End 13,348,298 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A1 Start 4,881,564 bp [2] End 4,910,557 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence islet of Langerhans oocyte secondary oocyte rectum internal globus pallidus right lobe of liver left lobe of thyroid gland endothelial cell body of pancreas Top expressed in maxillary prominence condyle ganglionic eminence abdominal wall primitive streak internal carotid artery external carotid artery cumulus cell medial ganglionic eminence endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding selenide, water dikinase activity GTP binding protein binding ATP binding protein homodimerization activity identical protein binding protein heterodimerization activity kinase activity Cellular component cytoplasm plasma membrane nuclear membrane membrane nucleus Biological process phosphorylation selenocysteine biosynthetic process selenium compound metabolic process tRNA seleno-modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22929 109079 Ensembl ENSG00000086475 ENSMUSG00000026662 UniProt P49903 Q5T5U7 Q8BH69 RefSeq (mRNA) NM_001195602 NM_001195604 NM_012247 NM_001375769 NM_001375770 NM_175400 RefSeq (protein) NP_001182531 NP_001182533 NP_036379 NP_001362698 NP_780609 NP_001349636 NP_001349637 NP_001349638 NP_001349639 Location (UCSC) Chr 10: 13.32 – 13.35 Mb Chr 2: 4.88 – 4.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene. ^{[5] [6]}

This protein functions as an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000086475 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026662 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Low SC; Harney JW; Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem. 270 (37): 21659–64. doi: 10.1074/jbc.270.37.21659 . PMID   7665581.
6. "Entrez Gene: SEPHS1 selenophosphate synthetase 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Tamura T, Yamamoto S, Takahata M, et al. (2004). "Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation". Proc. Natl. Acad. Sci. U.S.A. 101 (46): 16162–7. Bibcode:2004PNAS..10116162T. doi: 10.1073/pnas.0406313101 . PMC   528966 . PMID   15534230.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Saiki R, Nagata A, Kainou T, et al. (2005). "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans". FEBS J. 272 (21): 5606–22. doi: 10.1111/j.1742-4658.2005.04956.x . PMID   16262699. S2CID   13735213.
• Chung HJ, Yoon SI, Shin SH, et al. (2006). "p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression". J. Cell. Physiol. 209 (1): 131–41. doi:10.1002/jcp.20714. PMID   16786570. S2CID   24313890.