Selenoprotein O

SELENOO
Identifiers
Aliases	SELENOO , selenoprotein O, SELO
External IDs	OMIM: 607917; MGI: 1919007; HomoloGene: 69439; GeneCards: SELENOO; OMA:SELENOO - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,217,616 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	88,984,543 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; right lobe of liver; ; right hemisphere of cerebellum; ; cardia; ; granulocyte; ; mucosa of ileum; ; mucosa of transverse colon; ; apex of heart; ; thymus; ; skin of leg;
	Top expressed in
	left lobe of liver; ; right kidney; ; spermatocyte; ; proximal tubule; ; granulocyte; ; lacrimal gland; ; otolith organ; ; utricle; ; submandibular gland; ; human kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; ATP binding ; transferase activity ; nucleotidyltransferase activity ; metal ion binding ; protein adenylyltransferase activity ;
Cellular component	mitochondrion ;
Biological process	protein adenylylation ;
	Sources:Amigo / QuickGO
Orthologs
	83642
	223776
	ENSG00000073169
	ENSMUSG00000035757
	Q9BVL4
	Q9DBC0
	NM_031454
	NM_027905
	NP_113642
	NP_082181
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 04, 2024

Selenoprotein O is a protein that in humans is encoded by the SELENOO gene. ^[5]

Function

This gene encodes a selenoprotein, pseudokinase selenoprotein-O(SelO), that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The SELO protein Adenylates proteins involved in redox homeostasis. As a result this Selenoprotein is thought to be necessary for the cellular response to oxidative stress. ^[6]

Related Research Articles

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Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.

Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000073169 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035757 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Selenoprotein O" . Retrieved 2018-05-18.
↑ Sreelatha A (October 18, 2018). "Protein AMPylation by an Evolutionarily Conserved Pseudokinase". Cell. 175 (3): 809–821.e19. doi:10.1016/j.cell.2018.08.046. PMC 6524645 . PMID 30270044.

Selenoprotein O

Contents

Function

Related Research Articles

References

Further reading