Shootin 1

SHTN1
Identifiers
Aliases	SHTN1 , KIAA1598, shootin 1, shootin-1
External IDs	OMIM: 611171 MGI: 1918903 HomoloGene: 41249 GeneCards: SHTN1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q25.3 Start 116,881,477 bp [1] End 117,126,586 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 D2- D3 Start 58,961,788 bp [2] End 59,064,532 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus inferior ganglion of vagus nerve subthalamic nucleus optic nerve corpus callosum external globus pallidus endothelial cell medulla oblongata Region I of hippocampus proper superior vestibular nucleus Top expressed in otolith organ utricle suprachiasmatic nucleus trigeminal ganglion lacrimal gland Epithelium of stomach molar ganglionic eminence seminal vesicula sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function actin filament binding protein binding cadherin binding kinesin binding Cellular component perikaryon cell projection filopodium growth cone axon cytoskeleton lamellipodium cytoplasm microtubule microtubule associated complex microtubule cytoskeleton cell leading edge axonal growth cone perinuclear region of cytoplasm Biological process Cdc42 protein signal transduction cytoplasmic actin-based contraction involved in cell motility axonogenesis netrin-activated signaling pathway substrate-dependent cell migration, cell extension actin filament bundle retrograde transport multicellular organism development Ras protein signal transduction positive regulation of axon extension neuron projection morphogenesis endoplasmic reticulum polarization regulation of establishment of cell polarity regulation of neuron migration positive regulation of neuron migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57698 71653 Ensembl ENSG00000187164 ENSMUSG00000041362 UniProt A0MZ66 Q8K2Q9 RefSeq (mRNA) NM_001127211 NM_001258298 NM_001258299 NM_001258300 NM_018330 NM_001114312 NM_175172 RefSeq (protein) NP_001120683 NP_001245227 NP_001245228 NP_001245229 NP_060800 NP_001107784 NP_780381 Location (UCSC) Chr 10: 116.88 – 117.13 Mb Chr 19: 58.96 – 59.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Shootin 1 is a protein that in humans is encoded by the SHTN1 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000187164 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041362 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Shootin 1" . Retrieved 2017-05-26.

Further reading

• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC   1380225 . PMID   16385451.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC   2896464 . PMID   20379614.