Dichlorodiphenyltrichloroethane, commonly known as DDT, is a colorless, tasteless, and almost odorless crystalline chemical compound, an organochloride. Originally developed as an insecticide, it became infamous for its environmental impacts. DDT was first synthesized in 1874 by the Austrian chemist Othmar Zeidler. DDT's insecticidal action was discovered by the Swiss chemist Paul Hermann Müller in 1939. DDT was used in the second half of World War II to limit the spread of the insect-borne diseases malaria and typhus among civilians and troops. Müller was awarded the Nobel Prize in Physiology or Medicine in 1948 "for his discovery of the high efficiency of DDT as a contact poison against several arthropods".
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.
Mammography is the process of using low-energy X-rays to examine the human breast for diagnosis and screening. The goal of mammography is the early detection of breast cancer, typically through detection of characteristic masses or microcalcifications.
In epidemiology, a risk factor or determinant is a variable associated with an increased risk of disease or infection.
The Women's Health Initiative (WHI) was a series of clinical studies initiated by the U.S. National Institutes of Health (NIH) in 1991, to address major health issues causing morbidity and mortality in postmenopausal women. It consisted of three clinical trials (CT) and an observational study (OS). In particular, randomized controlled trials were designed and funded that addressed cardiovascular disease, cancer, and osteoporosis.
The abortion–breast cancer hypothesis posits that having an induced abortion can increase the risk of getting breast cancer. This hypothesis is at odds with mainstream scientific opinion and is rejected by major medical professional organizations; despite this, it continues to be widely propagated as pseudoscience, typically in service of an anti-abortion agenda.
Downwinders were individuals and communities in the intermountain between the Cascade and Rocky Mountain ranges primarily in Arizona, Nevada, New Mexico and Utah but also in Oregon, Washington, and Idaho who were exposed to radioactive contamination or nuclear fallout from atmospheric or underground nuclear weapons testing, and nuclear accidents.
Susan G. Komen is a breast cancer organization in the United States.
The National Women's Health Network (NWHN) is a non-profit women's health advocacy organization located in Washington, D.C. It was founded in 1975 by Barbara Seaman, Alice Wolfson, Belita Cowan, Mary Howell, and Phyllis Chesler. The stated mission of the organization is to give women a greater voice within the healthcare system. The NWHN researches and lobbies federal agencies on such issues as AIDS, reproductive rights, breast cancer, older women's health, and new contraceptive technologies. The Women's Health Voice, the NWHN's health information program, provides independent research on a variety of women's health topics.
Breast Cancer Action (BCAction) is a U.S.-based grassroots education and activist organization driven by and supporting people living with breast cancer. It was founded in 1990 by Elenore Pred, Susan Claymon, and Linda Reyes. Based in San Francisco, BCAction is known for understanding breast cancer not as an individual crisis, but a public health emergency, and for their commitment to social justice. The organization's mission is to achieve health justice for all women at risk of and living with breast cancer. BCAction is known for its Think Before You Pink campaign, launched in 2002, which encourages consumers to ask critical questions before buying pink ribbon products and holds corporations accountable for pinkwashing.
Mary-Claire King is an American geneticist. She was the first to show that breast cancer can be inherited due to mutations in the gene she called BRCA1. She studies human genetics and is particularly interested in genetic heterogeneity and complex traits. She studies the interaction of genetics and environmental influences and their effects on human conditions such as breast and ovarian cancer, inherited deafness, schizophrenia, HIV, systemic lupus erythematosus and rheumatoid arthritis. She has been the American Cancer Society Professor of the Department of Genome Sciences and of Medical Genetics in the Department of Medicine at the University of Washington since 1995.
Devra Lee Davis is an American epidemiologist, toxicologist, and author of three books about environmental hazards. She was founding director of the Center for Environmental Oncology at the University of Pittsburgh Cancer Institute, and is a former professor of epidemiology at University of Pittsburgh Graduate School of Public Health. She has served on several governmental and non-governmental organizations, conducting research and advocacy into effects of pesticides, asbestos, and wireless radiation on human health, especially cancers.
Risk factors for breast cancer may be divided into preventable and non-preventable. Their study belongs in the field of epidemiology. Breast cancer, like other forms of cancer, can result from multiple environmental and hereditary risk factors. The term "environmental", as used by cancer researchers, means any risk factor that is not genetically inherited.
Dorothy Goldin Rosenberg is a Canadian educator and film consultant. She researches, writes and speaks on environmental health, equality, social justice, economic justice, environmental justice, peace, and energy issues.
Breast cancer awareness is an effort to raise awareness and reduce the stigma of breast cancer through education about screening, symptoms, and treatment. Supporters hope that greater knowledge will lead to earlier detection of breast cancer, which is associated with higher long-term survival rates, and that money raised for breast cancer will produce a reliable, permanent cure.
High-dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose chemotherapy with autologous bone marrow transplant, was an ineffective treatment regimen for metastatic breast cancer, and later high-risk breast cancer, that was considered promising during the 1980s and 1990s. With an overall idea that more is better, this process involved taking cells from the person's bone marrow to store in a lab, then to give such high doses of chemotherapy drugs that the remaining bone marrow was destroyed, and then to inject the cells taken earlier back into the body as replacement. It was ultimately determined to be no more effective than normal treatment, and to have significantly higher side effects, including treatment-related death.
Silent Spring Institute is a nonprofit organization dedicated to studying and reporting primarily on breast cancer prevention, although its research covers other health-related topics as well.
Elizabeth M. Ward is an American scientist and researcher for the American Cancer Society. She received her PhD in Epidemiology from the University of Pennsylvania. Ward serves as the National Vice President of Intramural Research for the American Cancer Society and Chair of the World Trade Center Health Program Scientific and Technical Advisory Committee. She has held many positions in various cancer research organizations including a position on the National Cancer Institute's Board of Scientific Counselors for Clinical Sciences and Epidemiology. In recognition for her prominent work in the medical research field, she has received two different awards: U.S. Public Health Service Meritorious Service Medal and the Calum S. Muir Memorial Award. Ward's work is heavily centered around "cancer disparities, cancer treatment and outcomes, cancer surveillance, Occupational cancer and environmental cancer."
Marian Cecelia Johnson-Thompson is an American virologist who was a professor at the University of the District of Columbia. She was elected Fellow of the American Association for the Advancement of Science.
Clarice Ring Weinberg is an American biostatistician and epidemiologist who works for the National Institute of Environmental Health Sciences as principal investigator in the Biostatistics and Computational Biology Branch. Her research concerns environmental epidemiology, and its combination with genetics in susceptibility to disease, including running the Sister Study on how environmental and genetic effects can lead to breast cancer. She has also published highly cited research on fertility.
