Coxsackie B4 virus are enteroviruses that belong to the Picornaviridae family. These viruses can be found worldwide. They are positive-sense, single-stranded, non-enveloped RNA viruses with icosahedral geometry. Coxsackieviruses have two groups, A and B, each associated with different diseases. Coxsackievirus group A is known for causing hand-foot-and-mouth diseases while Group B, which contains six serotypes, can cause a varying range of symptoms like gastrointestinal distress myocarditis. Coxsackievirus B4 has a cell tropism for natural killer cells and pancreatic islet cells. Infection can lead to beta cell apoptosis which increases the risk of insulitis.
Picornaviruses are a group of related nonenveloped RNA viruses which infect vertebrates including fish, mammals, and birds. They are viruses that represent a large family of small, positive-sense, single-stranded RNA viruses with a 30 nm icosahedral capsid. The viruses in this family can cause a range of diseases including the common cold, poliomyelitis, meningitis, hepatitis, and paralysis.
Nosema apis is a microsporidian, a small, unicellular parasite recently reclassified as a fungus that mainly affects honey bees. It causes nosemosis, also called nosema, which is the most common and widespread of adult honey bee diseases. The dormant stage of N. apis is a long-lived spore which is resistant to temperature extremes and dehydration, and cannot be killed by freezing the contaminated comb. Nosemosis is a listed disease with the Office International des Epizooties (OIE).
Varroa destructor, the Varroa mite, is an external parasitic mite that attacks and feeds on honey bees and is one of the most damaging honey bee pests in the world. A significant mite infestation leads to the death of a honey bee colony, usually in the late autumn through early spring. Without management for Varroa mite, honey bee colonies typically collapse within 2 to 3 years in temperate climates. These mites can infest Apis mellifera, the western honey bee, and Apis cerana, the Asian honey bee. Due to very similar physical characteristics, this species was thought to be the closely related Varroa jacobsoni prior to 2000, but they were found to be two separate species after DNA analysis.
Dicistroviridae is a family of viruses in the order Picornavirales. Invertebrates, including aphids, leafhoppers, flies, bees, ants, and silkworms, serve as natural hosts. There are 15 species in this family, assigned to three genera. Diseases associated with this family include: DCV: increased reproductive potential. extremely pathogenic when injected with high associated mortality. CrPV: paralysis and death.
Varroa is a genus of parasitic mesostigmatan mites associated with honey bees, placed in its own family, Varroidae. The genus was named for Marcus Terentius Varro, a Roman scholar and beekeeper. The condition of a honeybee colony being infested with Varroa mites is called varroosis.
Aphthovirus is a viral genus of the family Picornaviridae. Aphthoviruses infect split-hooved animals, and include the causative agent of foot-and-mouth disease, Foot-and-mouth disease virus (FMDV). There are seven FMDV serotypes: A, O, C, SAT 1, SAT 2, SAT 3 and Asia 1, and four non-FMDV serotypes belonging to three additional species Bovine rhinitis A virus (BRAV), Bovine rhinitis B virus (BRBV) and Equine rhinitis A virus (ERAV).
Kakugo virus is a picorna-like virus most commonly found in the brains of worker bees. It is a subtype of the Deformed wing virus. The Kakugo virus, when resident in a bee's brain, can contribute to aggressive behaviors similar to those preeminent during a bee's guard phase in their life cycle. Kakugo is the first virus to have been found to cause aggressive behavior, although because the virus was only recently discovered to have such effects, research into the matter is limited.
Deformed wing virus (DWV) is a positive-strand RNA virus, one of 22 known viruses affecting honey bees. While most commonly infecting the honey bee, Apis mellifera, it has also been documented in other bee species, like Bombus terrestris, thus, indicating it may have a wider host specificity than previously anticipated. The virus was first isolated from a sample of symptomatic honeybees from Japan in the early 1980s and is currently distributed worldwide. It is found also in pollen baskets and commercially reared bumblebees. Its main vector in A. mellifera is the Varroa mite, which feeds on the hemolymph of the bee. It is named after what is usually the most obvious deformity it induces in the development of a honeybee pupa, which is shrunken and deformed wings, but other developmental deformities are often present. There are three known variants of Deformed Wing Virus, DWV-A, DWV-B, and DWV-C, of which the first two are vectored by the Varroa Destrcutor mite.
Iflaviridae is a family of positive sense RNA viruses insect-infecting viruses. Some of the insects commonly infected by iflaviruses include aphids, leafhoppers, flies, bees, ants, silkworms and wasps. The name "Ifla" is derived from the name "Infectious flacherie virus", a member species. There is one genus (Iflavirus) and 16 species in this family.
Varroa sensitive hygiene (VSH) is a behavioral trait of honey bees (Apis mellifera) in which bees detect and remove bee pupae that are infested by the parasitic mite Varroa destructor. V. destructor is considered to be the most dangerous pest problem for honey bees worldwide. VSH activity results in significant resistance to the mites.
Cricket paralysis virus (CrPV) is a paralytic disease affecting crickets. It was initially discovered in Australian field crickets by Carl Reinganum and his colleagues at the Victorian Plant Research Institute. The disease spread rapidly through a breeding colony as well as through a laboratory population causing about 95% mortality. This was the first recorded isolate of the virus and is generally referred to as CrPVvic to distinguish it from subsequent isolates.
Picornain 3C is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C’s endopeptidase activity is primarily responsible for the catalytic process of selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and with substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses. Picornain 3C are cysteine proteases related by amino acid sequence to trypsin-like serine proteases. Picornain 3C is encoded by enteroviruses, rhinoviruses, aphtoviruses and cardioviruses. These genera of picoviruses cause a wide range of infections in humans and mammals.
Chronic bee paralysis virus (CBPV) commonly affects adult Apis mellifera honey bees and causes a chronic paralysis that can easily spread to other members of a colony. Bees infected with CBPV begin to show symptoms after 5 days and die a few days after. Chronic bee paralysis virus infection is a factor that can contribute to or cause the sudden collapse of honeybee colonies. Since honeybees serve a vital role in ecological resilience, it is important to understand factors and diseases that threaten them.
Aparavirus is a genus of viruses in the order Picornavirales, in the family Dicistroviridae. Invertebrates, honeybee, and bumblebees serve as natural hosts. There are six species in this genus. Diseases associated with this genus include: ABPV: paralysis. This virus plays a role in sudden collapse of honey bee colonies infested with the parasitic mite varroa destructor.
Triatoma virus (TrV) is a virus belonging to the insect virus family Dicistroviridae. Within this family, there are currently 3 genera and 15 species of virus. Triatoma virus belongs to the genus Cripavirus. It is non-enveloped and its genetic material is positive-sense, single-stranded RNA. The natural hosts of triatoma virus are invertebrates. TrV is a known pathogen to Triatoma infestans, the major vector of Chagas disease in Argentina which makes triatoma virus a major candidate for biological vector control as opposed to chemical insecticides. Triatoma virus was first discovered in 1984 when a survey of pathogens of triatomes was conducted in the hopes of finding potential biological control methods for T. infestans.
The black queen cell virus (BQCV) is a virus that infects honey bees, specifically Apis mellifera, Apis florea, and Apis dorsata. Infection of the latter two species is more recent and can be attributed to genetic similarity and geographical closeness.
The evolution of the Sacbrood virus (SBV) is characterized by the genomic changes that have occurred in SBV since its initial discovery in 1913, which have enabled the virus to continuously infect a wide array of honeybee colonies. SBV is single stranded RNA virus (genus: Iflavirus) that most commonly infects honeybee larvae, and is known to wipe out entire honeybee colonies quickly. Due to SBV, there has been sharp declines in honey bee populations in Europe, as well as a 30% decline each year in U.S. colonies. Studies on the evolution of SBV have arisen in hopes to stop these colony devastations. SBV is one of the most widely studied honeybee viruses in terms of genomic analysis, leading to it having the highest number of complete genomes isolated compared to any other viruses known to honeybees. Through these genome studies, it has been found that there are two distinct lineages of SBV, each characterized by a high mutation rate, leading to multiple subtypes in both lineages. In studying how these lineages have evolved through time, new discoveries in their pathogenicity and different honeybee resistance mechanisms have been unveiled.
Snodgrassella alvi is a species of Gram-negative bacteria within the Neisseriaceae and was previously the only known species of the genus Snodgrassella. It was isolated and scientifically described in 2012 by Waldan K. Kwong and Nancy A. Moran, who named the bacteria after the American entomologist Robert Evans Snodgrass.
