Slp adaptor and csk interacting membrane protein

SCIMP
Identifiers
Aliases	SCIMP , C17orf87, UNQ5783, SLP adaptor and CSK interacting membrane protein
External IDs	OMIM: 614406; MGI: 3610314; HomoloGene: 52602; GeneCards: SCIMP; OMA:SCIMP - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.2 Start 5,208,920 bp [1] End 5,234,860 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B3 Start 70,681,758 bp [2] End 70,703,412 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte spleen lymph node appendix blood tonsil gallbladder smooth muscle tissue duodenum Top expressed in spleen bone marrow embryo right kidney thymus ileum jejunum colon adrenal gland liver More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane uropod membrane tetraspanin-enriched microdomain membrane leading edge membrane immunological synapse Biological process meiosis I positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388325 327957 Ensembl ENSG00000161929 ENSMUSG00000057135 UniProt Q6UWF3 Q3UU41 RefSeq (mRNA) NM_001271842 NM_207103 NM_001319190 NM_001045526 RefSeq (protein) NP_001258771 NP_001306119 NP_996986 NP_001038991 Location (UCSC) Chr 17: 5.21 – 5.23 Mb Chr 11: 70.68 – 70.7 Mb PubMed search [3] [4]
Wikidata
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SLP adaptor and CSK interacting membrane protein is a protein encoded by the SCIMP gene in humans ^[5]

Function

This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and localizes to the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].

References

1. GRCh38: Ensembl release 89: ENSG00000161929 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057135 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SLP adaptor and CSK interacting membrane protein" . Retrieved 2018-05-24.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.