Small nucleolar RNA TBR4

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snoTBR4
RF02787.svg
Predicted secondary structure and sequence conservation of Small nucleolar RNA TBR4
Identifiers
Rfam RF02787
Other data
Domain(s) Eukaryota
GO GO:0006396 ,GO:0005730
SO SO:0000593
PDB structures PDBe

Small nucleolar RNA TBR4 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA TBR4 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family direct site-specific 2'-O-methylation of substrate RNAs. [1]

TBR4 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipitation with anti-fibrillarin antibodies. [2] Together with TBR12, TBR6 and TBR2 it is a part of snoRNA gene cluster that is tandemly repeated. These 4 snoRNA genes are transcribed as a polycistronic RNA transcript. [3]

Other snoRNAs

Related Research Articles

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<span class="mw-page-title-main">Small nucleolar RNA SNORD43</span>

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<span class="mw-page-title-main">Small nucleolar RNA TBR17</span>

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<span class="mw-page-title-main">Small nucleolar RNA SNORD113</span>

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<span class="mw-page-title-main">Small nucleolar RNA TBR2</span>

Small nucleolar RNA TBR2 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA TBR12</span>

Small nucleolar RNA TBR12 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA TBR6</span>

Small nucleolar RNA TBR6 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

References

  1. ↑ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC   134041 . PMID   12215523.
  2. 1 2 Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (May 2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". The Journal of Biological Chemistry. 275 (19): 14767–76. doi: 10.1074/jbc.m001180200 . PMID   10747997.
  3. ↑ Dunbar DA, Chen AA, Wormsley S, Baserga SJ (August 2000). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–61. doi:10.1093/nar/28.15.2855. PMC   102681 . PMID   10908346.
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