Small nucleolar RNA TBR7

Last updated
Small nucleolar RNA TBR7
RF00295.jpg
Predicted secondary structure and sequence conservation of snoTBR7
Identifiers
SymbolsnoTBR7
Rfam RF00295
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, Small nucleolar RNA TBR7 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Contents

snoRNA TBR7 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1]

TBR7 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipitation with anti-fibrillarin antibodies. [2] It is predicted to guide the 2'O ribosome methylation of 18s ribosomal RNA (rRNA).

Together with TBR5 and TBR17 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA). [3] The cluster genes are produced as polycistronic RNA. [4]

See also

Small nucleolar RNA TBR2

Related Research Articles

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<span class="mw-page-title-main">Small nucleolar RNA Z102/R77</span>

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<span class="mw-page-title-main">Small nucleolar RNA R20</span>

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<span class="mw-page-title-main">Small nucleolar RNA R21</span>

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<span class="mw-page-title-main">Small nucleolar RNA SNORD25</span>

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<span class="mw-page-title-main">Small nucleolar RNA SNORD43</span>

In molecular biology, snoRNA U43 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD79</span> RNA molecule

In molecular biology, snoRNA U79 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD83</span>

In molecular biology, Small nucleolar RNA SNORD83 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA SNORD83 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. snoRNA SNORD83 are spliced from introns 5 and 4 of the BAT1 gene in mammals.

<span class="mw-page-title-main">Small nucleolar RNA TBR17</span>

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<span class="mw-page-title-main">Small nucleolar RNA TBR5</span>

In molecular biology, TBR5 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.

<span class="mw-page-title-main">Small nucleolar RNA Z194</span>

In molecular biology, Small nucleolar RNA Z194 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA Z278</span>

In molecular biology, Small nucleolar RNA Z278 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA TBR2</span>

Small nucleolar RNA TBR2 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA TBR4</span>

Small nucleolar RNA TBR4 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA TBR12</span>

Small nucleolar RNA TBR12 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA TBR6</span>

Small nucleolar RNA TBR6 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology . 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC   134041 . PMID   12215523.
  2. ↑ Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". J. Biol. Chem. 275 (19): 14767–76. doi: 10.1074/jbc.M001180200 . PMID   10747997.
  3. ↑ Roberts, T. G.; Sturm, N. R.; Yee, B. K.; Yu, M. C.; Hartshorne, T.; Agabian, N.; Campbell, D. A. (August 1998). "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and Cellular Biology. 18 (8): 4409–4417. doi:10.1128/mcb.18.8.4409. ISSN   0270-7306. PMC   109026 . PMID   9671450.
  4. ↑ Dunbar, D. A.; Chen, A. A.; Wormsley, S.; Baserga, S. J. (2000-08-01). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–2861. doi:10.1093/nar/28.15.2855. ISSN   1362-4962. PMC   102681 . PMID   10908346.


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