Small nucleolar RNA SNORA2

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Small nucleolar RNA SNORA2/SNORA34 family
RF00410.jpg
Predicted secondary structure and sequence conservation of SNORA2
Identifiers
SymbolSNORA2
Alt. SymbolssnoACA2
Rfam RF00410
Other data
RNA type Gene; snRNA; snoRNA; HACA-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000594
PDB structures PDBe

In molecular biology, SNORA2 (also known as ACA2) is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines. [1]

ACA2 was originally cloned from HeLa cells by association with GAR1 protein. It has the predicted hairpin-hinge-hairpin-tail structure and has the conserved H/ACA-box motifs. Originally two sequence variants of ACA2 were identified (called ACA2a and ACA2b). Both variants share approximately 66% sequence identity to another snoRNA characterised in the same study called ACA34 (also known as SNORA34). In the human genome all three snoRNAs (ACA2a, ACA2b and ACA34) are found to be located in the introns of the same gene. This gene encodes a predicted protein referred to as FLJ20436. [1]

Both variants of ACA2 have the same two predicted target sites (U4263 and U4282) in 28S ribosomal RNA (rRNA). ACA34 is also predicted to target one of these sites (U4282) in addition to U4269 of 28S rRNA. [1] [2] The sequence similarity, genomic location and the predicted target sites of these three snoRNAs suggest they have been generated by subsequent gene duplications during evolution. [1]

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Small nucleolar RNA SNORA55

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Small nucleolar RNA SNORA58

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Small nucleolar RNA SNORA61

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In molecular biology, Small nucleolar RNA SNORA11 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).

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Small nucleolar RNA SNORA79

In molecular biology, Small nucleolar RNA SNORA79 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).

References

  1. 1 2 3 4 Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC   480876 . PMID   15199136.
  2. ↑ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX   10.1.1.105.7552 . doi:10.1093/nar/gkj002. PMC   1347365 . PMID   16381836.
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