Small nucleolar RNA TBR17

Last updated
Small nucleolar RNA TBR17
RF00294.jpg
Predicted secondary structure and sequence conservation of snoTBR17
Identifiers
SymbolsnoTBR17
Rfam RF00294
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, Small nucleolar RNA TBR17 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Contents

snoRNA TBR17 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1]

TBR17 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipitation with anti-fibrillarin antibodies. [2] Together with TBR5 and TBR7 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA). [3] The cluster genes are produced as polycistronic RNAs. [4]

See also

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References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology . 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC   134041 . PMID   12215523.
  2. ↑ Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". J. Biol. Chem. 275 (19): 14767–14776. doi: 10.1074/jbc.M001180200 . PMID   10747997.
  3. ↑ Roberts, T. G.; Sturm, N. R.; Yee, B. K.; Yu, M. C.; Hartshorne, T.; Agabian, N.; Campbell, D. A. (August 1998). "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and Cellular Biology. 18 (8): 4409–4417. doi:10.1128/mcb.18.8.4409. ISSN   0270-7306. PMC   109026 . PMID   9671450.
  4. ↑ Dunbar, D. A.; Chen, A. A.; Wormsley, S.; Baserga, S. J. (2000-08-01). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–2861. doi:10.1093/nar/28.15.2855. ISSN   1362-4962. PMC   102681 . PMID   10908346.


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