Small nucleolar RNA SNORD90

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Small nucleolar RNA SNORD90
RF00579.jpg
Predicted secondary structure and sequence conservation of SNORD90
Identifiers
SymbolSNORD90
Alt. SymbolssnoHBII-295
Rfam RF00579
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, snoRNA SNORD90 (HBII-295) is a non-coding RNA that belongs to the family of C/D snoRNAs. Initially described as HBII-295 [1] this RNA has now been called SNORD70 by the HUGO Gene Nomenclature Committee. It is the human orthologue of the mouse MBII-295 and has no identified RNA target. [2] This RNA is expressed from an intron of the MNAB/OR1K1 gene.

There is evidence that SNORD90 is involved in guiding N6-methyladenosine (m6A) modifications onto target RNA transcripts [3] . Specifically, SNORD90 has been shown to increase m6A levels on neuregulin 3 (NRG3) leading to its down-regulation through recognition by YTHDF2 [3] .

Related Research Articles

<span class="mw-page-title-main">Small nucleolar RNA SNORD115</span>

In molecular biology, SNORD115 is a non-coding RNA (ncRNA) molecule known as a small nucleolar RNA which usually functions in guiding the modification of other non-coding RNAs. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. HBII-52 refers to the human gene, whereas RBII-52 is used for the rat gene and MBII-52 is used for naming the mouse gene.

<span class="mw-page-title-main">Small nucleolar RNA SNORD17</span>

In molecular biology, SNORD17 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD19</span> Type of RNA molecule found in eukaryotic cells

In molecular biology, SNORD19 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD42</span>

In molecular biology, snoRNA U42 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD45</span>

In molecular biology, snoRNA U45 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD64</span>

In molecular biology, SNORD64 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD65</span>

In molecular biology, SNORD65 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. SNORD19 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.

<span class="mw-page-title-main">Small nucleolar RNA SNORD66</span>

In molecular biology, SNORD66 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD67</span>

In molecular biology, SNORD67 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD69</span>

In molecular biology, snoRNA HBII-210 belongs to the C/D family of snoRNAs. It is the human orthologue of the mouse MBII-210 and is predicted to guide the 2'O-ribose methylation of large 28S rRNA on residue G4464.

<span class="mw-page-title-main">Small nucleolar RNA SNORD70</span>

In molecular biology, snoRNA SNORD70 (HBII-234) is a non-coding RNA that belongs to the C/D family of snoRNAs. It is the human orthologue of the mouse MBII-234 and is predicted to guide 2'O-ribose methylation of the small 18S rRNA on position A512. It is hosted, together with HBII-95, by the core C/D box snoRNA protein encoding gene NOP5/NOP58.

<span class="mw-page-title-main">Small nucleolar RNA SNORD71</span>

In molecular biology, snoRNA HBII-239 belongs to the family of C/D snoRNAs. It is the human orthologue of the mouse MBII-239 described and is predicted to guide 2'O-ribose methylation of 5.8S rRNA on residue U14.

<span class="mw-page-title-main">Small nucleolar RNA SNORD72</span>

In molecular biology, SNORD72 belongs to the C/D family of snoRNAs. It is the human orthologue of the mouse MBII-240 and is predicted to guide 2'O-ribose methylation of the large 28S rRNA at residue U4590.

<span class="mw-page-title-main">Small nucleolar RNA SNORD89</span>

In molecular biology, snoRNA HBII-289 belongs to the family of C/D snoRNAs. It is the human orthologue of the mouse MBII-289 and has no identified RNA target.

<span class="mw-page-title-main">Small nucleolar RNA SNORD111</span>

In molecular biology, Small Nucleolar RNA SNORD111 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD93</span>

In molecular biology, Small Nucleolar RNA SNORD93 is a non-coding RNA (ncRNA) molecule that functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the Eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and is also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD23</span>

In molecular biology, Small Nucleolar RNA SNORD23 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD88</span>

In molecular biology, Small Nucleolar RNA SNORD88 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD92</span>

In molecular biology, Small Nucleolar RNA SNORD92 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nucleolar RNA SNORD113</span>

In molecular biology, Small nucleolar RNA SNORD113 is a small nucleolar RNA molecule which is located in the imprinted human 14q32 locus and may play a role in the evolution and/or mechanism of the epigenetic imprinting process.

References

  1. ↑ Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMC   125495 . PMID   11387227.
  2. ↑ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX   10.1.1.105.7552 . doi:10.1093/nar/gkj002. PMC   1347365 . PMID   16381836.
  3. 1 2 Lin, Rixing; Kos, Aron; Lopez, Juan Pablo; Dine, Julien; Fiori, Laura M; Yang, Jennie; Ben-Efraim, Yair; Aouabed, Zahia; Ibrahim, Pascal; Mitsuhashi, Haruka; Wong, Tak Pan; Ibrahim, El Cherif; Belzung, Catherine; Blier, Pierre; Farzan, Faranak (2023-07-11). West, Anne E; Wong, Ma-Li (eds.). "SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants". eLife. 12: e85316. doi:10.7554/eLife.85316. ISSN   2050-084X. PMC   10335830 . PMID   37432876.
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