Small nucleolar RNA SNORD62

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Small nucleolar RNA SNORD62
RF00153.jpg
Identifiers
SymbolSNORD62
Alt. SymbolsU62
Rfam RF00153
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, snoRNA U62 (also known as SNORD62) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U62 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1]

In the human genome there are two identical copies of snoRNA U62 (called U62A and U62B) both of which are located within the introns of the same host gene which encodes a hypothetical protein (KIAA0515). [2] U62 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue A590. [3]

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References

  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC   134041 . PMID   12215523.
  2. Tycowski KT, Smith CM, Shu MD, Steitz JA (December 1996). "A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus". Proceedings of the National Academy of Sciences of the United States of America. 93 (25): 14480–5. Bibcode:1996PNAS...9314480T. doi: 10.1073/pnas.93.25.14480 . PMC   26158 . PMID   8962077.
  3. Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX   10.1.1.105.7552 . doi:10.1093/nar/gkj002. PMC   1347365 . PMID   16381836.