Small nucleolar RNA MBI-1

Last updated
Small nucleolar RNA SNORA23
RF00319.jpg
Identifiers
SymbolSNORA23
Alt. SymbolssnoMBI-1
Rfam RF00319
Other data
RNA type Gene; snRNA; snoRNA; H/ACA-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000594
PDB structures PDBe

In molecular biology, the Small nucleolar RNA MBI-1 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".

snoRNA MBI-1 was originally cloned from mouse brain tissues [1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and has the conserved H/ACA-box motifs.

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References

  1. Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMC   125495 . PMID   11387227.