Small nucleolar RNA SNORA32

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Small nucleolar RNA SNORA32
RF00421.jpg
Identifiers
SymbolSNORA32
Alt. SymbolssnoACA32
Rfam RF00421
Other data
RNA type Gene; snRNA; snoRNA; HACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594
PDB structures PDBe

In molecular biology, SNORA32 (also known as ACA32) is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines. [1]

Molecular biology branch of biology that deals with the molecular basis of biological activity

Molecular biology is a branch of biology that concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions. Writing in Nature in 1961, William Astbury described molecular biology as:

...not so much a technique as an approach, an approach from the viewpoint of the so-called basic sciences with the leading idea of searching below the large-scale manifestations of classical biology for the corresponding molecular plan. It is concerned particularly with the forms of biological molecules and [...] is predominantly three-dimensional and structural – which does not mean, however, that it is merely a refinement of morphology. It must at the same time inquire into genesis and function.

Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs, which are associated with methylation, and the H/ACA box snoRNAs, which are associated with pseudouridylation. SnoRNAs are commonly referred to as guide RNAs but should not be confused with the guide RNAs that direct RNA editing in trypanosomes.

Uridine chemical compound

Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N1-glycosidic bond.

Related Research Articles

Small nucleolar RNA SNORA1

NORA1 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA13

In molecular biology, SNORA13 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA14

SNORA14 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA17

In molecular biology, SNORA17 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines. Specifically, it is predicted to guide pseudouridylation of the 28S rRNA at positions U4659 and U4598. It shares the same host gene together with ACA43.

Small nucleolar RNA SNORA18

In molecular biology, SNORA18 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA20

In molecular biology, SNORA20 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA22

SNORA22 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA24

In molecular biology, SNORA24 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA25

In molecular biology, SNORA25 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA27

SNORA27 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA33

In molecular biology, SNORA33 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA38

SNORA38 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA4

In molecular biology, SNORA4 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA42

In molecular biology, SNORA42 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA5

In molecular biology, SNORA5 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA52

Small nucleolar RNA SNORA52 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA52 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA52 is predicted to guide the pseudouridylation of U3823 of 28S ribosomal RNA (rRNA). Pseudouridylation is the to the different isomeric form pseudouridine.

Small nucleolar RNA SNORA61

Small nucleolar RNA SNORA61 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA61 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA61 is predicted to guide the pseudouridylation of U2495 of 28S ribosomal RNA (rRNA). Pseudouridylation is the to the different isomeric form pseudouridine.

Small nucleolar RNA SNORA8

In molecular biology, SNORA8 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA9

SNORA9 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.

Small nucleolar RNA SNORA64/SNORA10 family

In molecular biology, small nucleolar RNA SNORA10 and small nuclear RNA SNORA64 are homologous members of the H/ACA class of small nucleolar RNA (snoRNA). This family of ncRNAs involved in the maturation of ribosomal RNA. snoRNA in this family act as guides in the modification of uridines to pseudouridines. This family includes the human snoRNAs U64 and ACA10 and mouse MBI-29.

References

  1. ↑ Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC   480876 . PMID   15199136.
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