Small nucleolar RNA SNORA24 | |
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![]() Predicted secondary structure and sequence conservation of SNORA24 | |
Identifiers | |
Symbol | SNORA24 |
Alt. Symbols | snoACA24 |
Rfam | RF00399 |
Other data | |
RNA type | Gene; snRNA; snoRNA; HACA-box |
Domain(s) | Eukaryota |
GO | 0006396 0005730 |
SO | 0000594 |
PDB structures | PDBe |
In molecular biology, SNORA24 (also known as ACA24) is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines. [1]
Molecular biology is a branch of biology that concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions. Writing in Nature in 1961, William Astbury described molecular biology as:
...not so much a technique as an approach, an approach from the viewpoint of the so-called basic sciences with the leading idea of searching below the large-scale manifestations of classical biology for the corresponding molecular plan. It is concerned particularly with the forms of biological molecules and [...] is predominantly three-dimensional and structural – which does not mean, however, that it is merely a refinement of morphology. It must at the same time inquire into genesis and function.
Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs, which are associated with methylation, and the H/ACA box snoRNAs, which are associated with pseudouridylation. SnoRNAs are commonly referred to as guide RNAs but should not be confused with the guide RNAs that direct RNA editing in trypanosomes.
Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N1-glycosidic bond.
NORA1 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, SNORA13 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
SNORA14 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, SNORA17 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines. Specifically, it is predicted to guide pseudouridylation of the 28S rRNA at positions U4659 and U4598. It shares the same host gene together with ACA43.
In molecular biology, SNORA18 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, SNORA20 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
SNORA22 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, SNORA25 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
SNORA27 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, SNORA32 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, SNORA33 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
SNORA38 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, SNORA4 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, SNORA42 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, SNORA5 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
Small nucleolar RNA SNORA52 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA52 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA52 is predicted to guide the pseudouridylation of U3823 of 28S ribosomal RNA (rRNA). Pseudouridylation is the to the different isomeric form pseudouridine.
Small nucleolar RNA SNORA61 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. ACA61 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA61 is predicted to guide the pseudouridylation of U2495 of 28S ribosomal RNA (rRNA). Pseudouridylation is the to the different isomeric form pseudouridine.
In molecular biology, SNORA8 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
SNORA9 is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.
In molecular biology, small nucleolar RNA SNORA10 and small nuclear RNA SNORA64 are homologous members of the H/ACA class of small nucleolar RNA (snoRNA). This family of ncRNAs involved in the maturation of ribosomal RNA. snoRNA in this family act as guides in the modification of uridines to pseudouridines. This family includes the human snoRNAs U64 and ACA10 and mouse MBI-29.
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