Small nucleolar RNA SNORD98

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Small Nucleolar RNA SNORD98
RF00607.jpg
Identifiers
SymbolSNORD98
Rfam RF00607
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, Small Nucleolar RNA SNORD98 (also known as HBII-419) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNORD98 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2′-O-methylation of substrate RNAs. [1] SNORD98 is predicted to guide the 2'0-ribose methylation of 18S ribosomal RNA (rRNA) residue G867. [2]

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Small nucleolar RNA SNORD19

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Small nucleolar RNA SNORD48

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Small nucleolar RNA SNORD54

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Small nucleolar RNA SNORD58

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Small nucleolar RNA SNORD63

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Small nucleolar RNA SNORD65

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Small nucleolar RNA SNORD73

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Small nucleolar RNA SNORD100

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Small nucleolar RNA SNORD110

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Small nucleolar RNA SNORD111

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Small nucleolar RNA SNORD99

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Small nucleolar RNA SNORD23

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Small nucleolar RNA SNORD75

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Small nucleolar RNA SNORD92

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References

  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2′-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC   134041 . PMID   12215523.
  2. Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158–162. CiteSeerX   10.1.1.105.7552 . doi:10.1093/nar/gkj002. PMC   1347365 . PMID   16381836.