Small nucleolar RNA SNORA74 | |
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Identifiers | |
Symbol | SNORA74 |
Alt. Symbols | U19 |
Rfam | RF00090 |
Other data | |
RNA type | Gene; snRNA; snoRNA; H/ACA-box |
Domain(s) | Eukaryota |
GO | GO:0006396 GO:0005730 |
SO | SO:0000594 |
PDB structures | PDBe |
In molecular biology, Small nucleolar RNA SNORA74 (U19) belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs. [1] Targets may include ribosomal and spliceosomal RNAs but the exact functions of many snoRNAs, including U19, are not confirmed. Co-precipitation of U19 snoRNA with RNase MRP RNA suggests that U19 may be involved in pre-rRNA processing. [2] [3]
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