YTHDF2

YTHDF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RDN, 4RDO, 4WQN
Identifiers
Aliases	YTHDF2 , HGRG8, NY-REN-2, CAHL, YTH N6-methyladenosine RNA binding protein 2, DF2
External IDs	OMIM: 610640 MGI: 2444233 HomoloGene: 32302 GeneCards: YTHDF2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,769,775 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	131,939,614 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; quadriceps femoris muscle; ; ganglionic eminence; ; islet of Langerhans; ; stromal cell of endometrium; ; bone marrow cells; ; skin of abdomen; ; smooth muscle tissue; ; thymus; ; rectum;
	Top expressed in
	maxillary prominence; ; medial ganglionic eminence; ; hand; ; abdominal wall; ; cumulus cell; ; endocardial cushion; ; vas deferens; ; somite; ; primitive streak; ; pineal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	N6-methyladenosine-containing RNA binding ; protein binding ; RNA binding ;
Cellular component	cytosol ; P-body ; nucleus ; cytoplasm ; microtubule organizing center ; cytoplasmic ribonucleoprotein granule ;
Biological process	humoral immune response ; positive regulation of cap-independent translational initiation ; regulation of mRNA stability ; embryonic morphogenesis ; mRNA destabilization ; oocyte maturation ; negative regulation of Notch signaling pathway ; endothelial to hematopoietic transition ; regulation of hematopoietic stem cell differentiation ; regulation of meiotic cell cycle process involved in oocyte maturation ; cell differentiation ; oogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	51441
	213541
	ENSG00000198492
	ENSMUSG00000040025
	Q9Y5A9
	Q91YT7
	NM_016258 ; NM_001172828 ; NM_001173128
	NM_145393
	NP_001166299 ; NP_001166599 ; NP_057342
	NP_663368
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 30, 2023

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene. ^[5]

Function

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline-rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. Also, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively, spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012].

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<i>N</i><sup>6</sup>-Methyladenosine Modification in mRNA, DNA

N⁶-Methyladenosine (m⁶A) was originally identified and partially characterised in the 1970s, and is an abundant modification in mRNA and DNA. It is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA (snRNA) as well as several long non-coding RNA, such as Xist.

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RNA demethylase ALKBH5 is a protein that in humans is encoded by the ALKBH5 gene.

Mediator complex subunit 19 (Med19) is a protein that in humans is encoded by the MED19 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198492 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040025 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: YTH N6-methyladenosine RNA binding protein 2" . Retrieved 2017-12-24.

Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi: 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . PMID 10508479.
Cardelli M, Marchegiani F, Cavallone L, Olivieri F, Giovagnetti S, Mugianesi E, Moresi R, Lisa R, Franceschi C (2006). "A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity". J. Gerontol. A Biol. Sci. Med. Sci. 61 (6): 547–56. doi: 10.1093/gerona/61.6.547 . PMID 16799135.
Cardelli M, Marchegiani F, Cavallone L, Olivieri F, Giovagnetti S, Mugianesi E, Moresi R, Lisa R, Franceschi C (2006). "A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity". J. Gerontol. A Biol. Sci. Med. Sci. 61 (6): 547–56. doi: 10.1093/gerona/61.6.547 . PMID 16799135.
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C (2014). "N6-methyladenosine-dependent regulation of messenger RNA stability". Nature. 505 (7481): 117–20. Bibcode:2014Natur.505..117W. doi:10.1038/nature12730. PMC 3877715 . PMID 24284625.
Li F, Zhao D, Wu J, Shi Y (2014). "Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition". Cell Res. 24 (12): 1490–2. doi:10.1038/cr.2014.153. PMC 4260351 . PMID 25412658.
Zhu T, Roundtree IA, Wang P, Wang X, Wang L, Sun C, Tian Y, Li J, He C, Xu Y (2014). "Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine". Cell Res. 24 (12): 1493–6. doi:10.1038/cr.2014.152. PMC 4260350 . PMID 25412661.
Xu C, Liu K, Ahmed H, Loppnau P, Schapira M, Min J (2015). "Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins". J. Biol. Chem. 290 (41): 24902–13. doi: 10.1074/jbc.M115.680389 . PMC 4598999 . PMID 26318451.
Tirumuru N, Zhao BS, Lu W, Lu Z, He C, Wu L (2016). "N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression". eLife. 5. doi: 10.7554/eLife.15528 . PMC 4961459 . PMID 27371828.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198492 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040025 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: YTH N6-methyladenosine RNA binding protein 2" . Retrieved 2017-12-24.

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YTHDF2

Contents

Function

See also

Related Research Articles

References

Further reading