Snail slime

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A crawling individual of the small land snail Cochlicella barbara leaving a slime trail behind it. Cochlicella barbara 11-10-2011.jpg
A crawling individual of the small land snail Cochlicella barbara leaving a slime trail behind it.

Snail slime is a kind of mucus (an external bodily secretion) produced by snails, which are gastropod mollusks. Land snails and slugs both produce mucus, as does every other kind of gastropod, from marine, freshwater, and terrestrial habitats. The reproductive system of gastropods also produces mucus internally from special glands.

Contents

Chemically, the mucus produced by land-living gastropodes belongs to the class of glycosaminoglycans (previously called mucopolysaccharides). Externally, one kind of mucus is produced by the foot of the gastropod and is usually used for crawling. The other kind of external mucus has evolved to coat the external parts of the gastropod's body; in land species, this coating helps prevent desiccation of the exposed soft tissues. The foot mucus of a gastropod has some of the qualities of glue and some of the qualities of a lubricant, allowing land snails to crawl up vertical surfaces without falling off. [1]

The slime trail that a land gastropod leaves behind is often visible as a silvery track on surfaces such as stone or concrete.

Description

A dendrogram (tree) showing the genetic similarity of Cornu aspersum mucus between 71 proteins against ~180 related proteins that were found previously in other mollusks. Will-it-slip-or-will-i.jpg
A dendrogram (tree) showing the genetic similarity of Cornu aspersum mucus between 71 proteins against ~180 related proteins that were found previously in other mollusks.

Mucus is a gel consisting of a polymer network that functions as a protective layer for the integument and mucosal surfaces of both elementary animals and mammals. [3]

The mucus of gastropods is not only used as a coating to cover the surfaces on which the snail crawls and a coating to cover the exposed soft parts of the body but also sometimes to allow a resting snail to adhere passively to surfaces, such as rock. [2] Gastropod mucus adhesion uses a temporary sealing structure called the epiphragm. [4] Mucus is produced by a large gland located below the snail's mouth. [5]

The foot of gastropods is covered with a thin layer of this mucus, which is used for a variety of functions, including locomotion, adherence, lubrication, repulsing predators, recognizing other snails, following a trail to a known destination and during reproduction. The discharge looks like a gel and it contains approximately 91 to 98% water by weight, depending on the species, combined with a small amount of high molecular weight glycoproteins. [6] In Cornu aspersum, these glycoproteins reach weights of 82, 97 and 175 kDa.

The common garden snail Cornu aspersum Cornu aspersum (Segrijnslak).jpg
The common garden snail Cornu aspersum

Locomotion

Locomotion in snails comes from a series of muscle contractions called pedal waves and relaxations called inter waves. [7] The waves created help propel the snail forward whilst pushing the thin layer of mucus used as lubrication, behind them. In an Experimental Biology article, research has been presented showing that each wave is indeed creating a propulsive force using the mucus to reduce resistance.

Land mollusks travel by adhesive locomotion via muscular waves that propagate from tail to head. The snail mucus has an adapted flow behavior that allows transmittance of the muscular force while maintaining adhesion. [8] [9] When inactive, many mollusks of both marine and terrestrial species, use the secretion to stick to various surfaces. However, although it is so diluted that it can commonly act as a lubricant, it can also have strong adhesive properties. [10] In their unique mating ritual, Limax maximus use a mucus thread to suspend themselves from elevated locations like tree branches. [9] In Cornu aspersum, there are three types of secretion. One type is translucent and not adhesive, the kind that the snail leaves behind as it moves (the slime trail), another is similar but thicker, condensed, more viscous and elastic, which is used to adhere to various surfaces, and a third viscous coating on the dorsal surface that is a protective barrier. [2] Both are clearly differentiated by the type of proteins present in them. [11]

Slime Production

A snail releases different kinds of mucus depending on the way it is stimulated. When the stimulation is normal, the slime is viscous (sticky) but if the snail is disturbed continuously or even violently, it releases clear foamy secretions. If the snail is sexually aroused the slime it releases is clear and viscous. In the case of Cornu aspersum , the discharge is composed of synthesized products from various types of secretory glands. These are all single-cell glands found in connective tissue and they secrete their products via pores that pass between the epidermal cells. They are of various shapes and usually have a long excretory duct. There are eight different types of secreting glands. Four of these different types secrete protein, calcium, pigments and lipids. [12]

Medical Uses

Some of the characteristics of snail slime have shown to be useful in Chinese medicine. Traditional Chinese medicine has used slime in a variety of ways to treat a variety of illnesses and cosmetic issues. It has also been used as skin creams for wrinkles and dry skin in cosmetics." [13] The Chinese also have used the color-fast dry qualities of snail slime as a natural dye that represented wealth and power. The mucus has shown to be proficient in several biological activities including antimicrobial, antioxidant, anti-tyrosinase, and anti-tumoral activities. [14]

A new generation of tissue adhesive has been developed by using natural adhesion phenomena and mechanisms, such as snail mucus gel, which exhibits excellent haemostatic activity, biocompatibility, and biodegradability. It is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. [15]

The slime trail is so thick that the animal is able to cross a sharp blade without harm. Helix pomatia on razor blade.jpg
The slime trail is so thick that the animal is able to cross a sharp blade without harm.

See also

Related Research Articles

<span class="mw-page-title-main">Snail</span> Shelled gastropod

A snail is a shelled gastropod. The name is most often applied to land snails, terrestrial pulmonate gastropod molluscs. However, the common name snail is also used for most of the members of the molluscan class Gastropoda that have a coiled shell that is large enough for the animal to retract completely into. When the word "snail" is used in this most general sense, it includes not just land snails but also numerous species of sea snails and freshwater snails. Gastropods that naturally lack a shell, or have only an internal shell, are mostly called slugs, and land snails that have only a very small shell are often called semi-slugs.

<span class="mw-page-title-main">Mucus</span> Secretion produced by mucous membranes

Mucus is a slippery aqueous secretion produced by, and covering, mucous membranes. It is typically produced from cells found in mucous glands, although it may also originate from mixed glands, which contain both serous and mucous cells. It is a viscous colloid containing inorganic salts, antimicrobial enzymes, immunoglobulins, and glycoproteins such as lactoferrin and mucins, which are produced by goblet cells in the mucous membranes and submucosal glands. Mucus serves to protect epithelial cells in the linings of the respiratory, digestive, and urogenital systems, and structures in the visual and auditory systems from pathogenic fungi, bacteria and viruses. Most of the mucus in the body is produced in the gastrointestinal tract.

<span class="mw-page-title-main">Mucin</span> Glycoprotein

Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. They often take an inhibitory role. Some mucins are associated with controlling mineralization, including nacre formation in mollusks, calcification in echinoderms and bone formation in vertebrates. They bind to pathogens as part of the immune system. Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer.

<span class="mw-page-title-main">Goblet cell</span> Epithelial cells that secrete mucins

Goblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin 2 in the lower gastrointestinal tract, and mucin 5AC in the respiratory tract. The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under stress. The term goblet refers to the cell's goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucus laden granules; its basal portion lacks these granules and is shaped like a stem.

<i>Cornu aspersum</i> Species of edible land snail

Cornu aspersum, known by the common name garden snail, is a species of land snail in the family Helicidae, which includes some of the most familiar land snails. Of all terrestrial molluscs, this species may well be the most widely known. It was classified under the name Helix aspersa for over two centuries, but the prevailing classification now places it in the genus Cornu.

<i>Brachylaima</i> Genus of flukes

Brachylaima is a genus of trematodes that can infect the gastrointestinal tract of human beings.

<span class="mw-page-title-main">Heliciculture</span> Snail farming

Heliciculture, commonly known as snail farming, is the process of raising edible land snails, primarily for human consumption or cosmetic use. The meat and snail eggs a.k.a. white caviar can be consumed as escargot and as a type of caviar, respectively.

<i>Lissachatina fulica</i> Species of land snail

Lissachatina fulica is a species of large land snail that belongs in the subfamily Achatininae of the family Achatinidae. It is also known as the Giant African land snail. It shares the common name "giant African snail" with other species of snails such as Achatina achatina and Archachatina marginata. This snail species has been considered a significant cause of pest issues around the world. Internationally, it is the most frequently occurring invasive species of snail.

<span class="mw-page-title-main">Helicidae</span> Family of gastropods

Helicidae is a large, diverse family of western Palaearctic, medium to large-sized, air-breathing land snails, sometimes called the "typical snails." It includes some of the largest European land snails, several species are common in anthropogenic habitats, and some became invasive on other continents. A number of species in this family are valued as food items, including Cornu aspersum the brown or garden snail, and Helix pomatia. The biologies of these two species in particular have been thoroughly studied and documented.

An ovotestis is a gonad with both testicular and ovarian aspects. In humans, ovotestes are an infrequent anatomical variation associated with gonadal dysgenesis. The only mammals where ovotestes are not symptomatic of a disorder are moles, wherein females possess ovotestes along with a masculinized clitoris. These ovotestes in nonpregnant female moles secrete eight times as much testosterone as the ovotestes of pregnant moles. In invertebrates that are normally hermaphroditic, such as most gastropods in the clade Eupulmonata, an ovotestis is a common feature of the reproductive anatomy.

Bioadhesives are natural polymeric materials that act as adhesives. The term is sometimes used more loosely to describe a glue formed synthetically from biological monomers such as sugars, or to mean a synthetic material designed to adhere to biological tissue.

<span class="mw-page-title-main">Land snail</span> Common name for many species of snail

A land snail is any of the numerous species of snail that live on land, as opposed to the sea snails and freshwater snails. Land snail is the common name for terrestrial gastropod mollusks that have shells. However, it is not always easy to say which species are terrestrial, because some are more or less amphibious between land and fresh water, and others are relatively amphibious between land and salt water.

<span class="mw-page-title-main">Foveolar cell</span> Mucus-producing cells in stomach lining protective against gastric acid

Foveolar cells or surface mucous cells are mucus-producing cells which cover the inside of the stomach, protecting it from the corrosive nature of gastric acid. These cells line the gastric mucosa and the gastric pits. Mucous neck cells are found in the necks of the gastric glands. The mucus-secreting cells of the stomach can be distinguished histologically from the intestinal goblet cells, another type of mucus-secreting cell.

<span class="mw-page-title-main">Slug</span> Shell-less terrestrial gastropod mollusc

Slug, or land slug, is a common name for any apparently shell-less terrestrial gastropod mollusc. The word slug is also often used as part of the common name of any gastropod mollusc that has no shell, a very reduced shell, or only a small internal shell, particularly sea slugs and semi-slugs.

<span class="mw-page-title-main">Love dart</span> Darts that some snails shoot into each other during mating

A love dart is a sharp, calcareous or chitinous dart which some hermaphroditic land snails and slugs create. Love darts are both formed and stored internally in a dart sac. These darts are made in sexually mature animals only, and are used as part of the sequence of events during courtship, before actual mating takes place. Darts are quite large compared to the size of the animal: in the case of the semi-slug genus Parmarion, the length of a dart can be up to one fifth that of the semi-slug's foot.

<span class="mw-page-title-main">Suprapedal gland</span> Land located inside the front end of the foot of gastropods

The suprapedal gland or mucous pedal gland is an anatomical feature found in some snails and slugs. It is a gland located inside the front end of the foot of gastropods.

Aelurostrongylus abstrusus is a species of nematode from the family Angiostrongylidae.

<span class="mw-page-title-main">Bovine submaxillary mucin coatings</span> Surface treatment for biomaterials

Bovine submaxillary mucin (BSM) coatings are a surface treatment provided to biomaterials intended to reduce the growth of disadvantageous bacteria and fungi such as S. epidermidis, E. coli, and Candida albicans. BSM is a substance extracted from the fresh salivary glands of cows. It exhibits unique physical properties, such as high molecular weight and amphiphilicity, that allow it to be used for many biomedical applications.

<span class="mw-page-title-main">Arthropod adhesion</span>

Arthropods, including insects and spiders, make use of smooth adhesive pads as well as hairy pads for climbing and locomotion along non-horizontal surfaces. Both types of pads in insects make use of liquid secretions and are considered 'wet'. Dry adhesive mechanisms primarily rely on Van der Waals' forces and are also used by organisms other than insects. The fluid provides capillary and viscous adhesion and appears to be present in all insect adhesive pads. Little is known about the chemical properties of the adhesive fluids and the ultrastructure of the fluid-producing cells is currently not extensively studied. Additionally, both hairy and smooth types of adhesion have evolved separately numerous times in insects. Few comparative studies between the two types of adhesion mechanisms have been done, and there is a lack of information regarding the forces that can be supported by these systems in insects. Additionally, tree frogs and some mammals such as the arboreal possum and bats also make use of smooth adhesive pads. The use of adhesive pads for locomotion across non-horizontal surfaces is a trait that evolved separately in different species, making it an example of convergent evolution. The power of adhesion allows these organisms to be able to climb on almost any substance.

<span class="mw-page-title-main">Slime coat</span> Fish integument

The slime coat is the coating of mucus covering the body of all fish. An important part of fish anatomy, it serves many functions, depending on species, ranging from locomotion, care and feeding of offspring, to resistance against diseases and parasites.

References

  1. "Snail slime substitutes". Royal Society of Chemistry. 2020-03-05. Retrieved 2024-06-02.
  2. 1 2 3 Cerullo, Antonio R.; McDermott, Maxwell B.; Pepi, Lauren E.; Liu, Zhi-Lun; Barry, Diariou; Zhang, Sheng; Yang, Xu; Chen, Xi; Azadi, Parastoo; Holford, Mande; Braunschweig, Adam B. (2023-09-02). "Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions". Nature Communications. 14 (1): 5361. Bibcode:2023NatCo..14.5361C. doi: 10.1038/s41467-023-41094-z . ISSN   2041-1723. PMC   10475054 . PMID   37660066.
  3. Verdugo, P.; Deyrup-Olsen, I.; Aitken, M.; Villalon, M.; Johnson, D. (February 1987). "Molecular Mechanism of Mucin Secretion: I. The Role of Intragranular Charge Shielding". Journal of Dental Research. 66 (2): 506–508. doi:10.1177/00220345870660022001. PMID   3476567.
  4. Hickman, C., Roberts, L. and Larson, A. (2002). Principios integrales de Zoología. 11°. Ed. McGraw- Hill Interamericana. España. Pp 328, 329, 330, 333. 98 (Spanish translation)
  5. Ruppert, Edward E.; Fox, Richard S.; Barnes, Robert D. (2004). Invertebrate zoology: a functional evolutionary approach (7th ed.). Belmont, CA: Thomson-Brooks/Cole. ISBN   9780030259821. OCLC   752875516.
  6. Denny, Mark W. (February 1984). "Mechanical Properties of Pedal Mucus and Their Consequences for Gastropod Structure and Performance". American Zoologist. 24 (1): 23–36. doi:10.1093/icb/24.1.23.
  7. Lai, Janice H.; del Alamo, Juan C.; Rodríguez-Rodríguez, Javier; Lasheras, Juan C. (2010-11-15). "The mechanics of the adhesive locomotion of terrestrial gastropods". Journal of Experimental Biology. 213 (22): 3920–3933. doi:10.1242/jeb.046706. ISSN   1477-9145. PMC   6514465 . PMID   21037072.
  8. Ewoldt, Randy H.; Clasen, Christian; Hosoi, A. E.; McKinley, Gareth H. (2007). "Rheological fingerprinting of gastropod pedal mucus and synthetic complex fluids for biomimicking adhesive locomotion". Soft Matter. 3 (5): 634–643. Bibcode:2007SMat....3..634E. doi:10.1039/B615546D. PMID   32900028.
  9. 1 2 Rühs, Patrick A.; Bergfreund, Jotam; Bertsch, Pascal; Gstöhl, Stefan J.; Fischer, Peter (2021). "Complex fluids in animal survival strategies". Soft Matter. 17 (11): 3022–3036. arXiv: 2005.00773 . Bibcode:2021SMat...17.3022R. doi: 10.1039/D1SM00142F . PMID   33729256.
  10. Pawlicki, JM; Pease, LB; Pierce, CM; Startz, TP; Zhang, Y; Smith, AM (March 2004). "The effect of molluscan glue proteins on gel mechanics". The Journal of Experimental Biology. 207 (Pt 7): 1127–35. doi:10.1242/jeb.00859. PMID   14978055.
  11. Ibid.
  12. Campion, Mary (1 June 1961). "The Structure and Function of the Cutaneous Glands in Helix aspersa". Journal of Cell Science. S3-102 (58): 195–216. doi:10.1242/jcs.s3-102.58.195.
  13. Yu, Dan-Ni; Tian, Dan; He, Ji-Huan (2018-06-01). "Snail-based nanofibers". Materials Letters. 220: 5–7. Bibcode:2018MatL..220....5Y. doi:10.1016/j.matlet.2018.02.076. ISSN   0167-577X. S2CID   139128984.
  14. Noothuan, Nattaphop; Apitanyasai, Kantamas; Panha, Somsak; Tassanakajon, Anchalee (2021-04-15). "Snail mucus from the mantle and foot of two land snails, Lissachatina fulica and Hemiplecta distincta, exhibits different protein profile and biological activity". BMC Research Notes. 14 (1): 138. doi: 10.1186/s13104-021-05557-0 . ISSN   1756-0500. PMC   8050916 . PMID   33858499.
  15. Deng, Tuo; Gao, Dongxiu; Song, Xuemei; Zhou, Zhipeng; Zhou, Lixiao; Tao, Maixian; Jiang, Zexiu; Yang, Lian; Luo, Lan; Zhou, Ankun; Hu, Lin; Qin, Hongbo; Wu, Mingyi (2023-01-24). "A natural biological adhesive from snail mucus for wound repair". Nature Communications. 14 (1): 396. Bibcode:2023NatCo..14..396D. doi:10.1038/s41467-023-35907-4. ISSN   2041-1723. PMC   9873654 . PMID   36693849. S2CID   256230314.
  16. "Slime and reason". Metro. 2006-09-07. Retrieved 2021-03-15.

Further reading