Snail slime

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A crawling individual of the small land snail Cochlicella barbara leaving a slime trail behind it. Cochlicella barbara 11-10-2011.jpg
A crawling individual of the small land snail Cochlicella barbara leaving a slime trail behind it.

Snail slime ( mucopolysaccharide ) is a kind of mucus (an external bodily secretion) produced by snails, which are gastropod mollusks. Land snails and slugs both produce mucus, as does every other kind of gastropod, from marine, freshwater, and terrestrial habitats. The reproductive system of gastropods also produces mucus internally from special glands.

Contents

Externally, one kind of mucus is produced by the foot of the gastropod and is usually used for crawling. The other kind of external mucus has evolved to coat the external parts of the gastropod's body; in land species, this coating helps prevent desiccation of the exposed soft tissues. The foot mucus of a gastropod has some of the qualities of glue and some of the qualities of a lubricant, allowing land snails to crawl up vertical surfaces without falling off. [1]

The slime trail that a land gastropod leaves behind is often visible as a silvery track on surfaces such as stone or concrete.

Description

A dendrogram (tree) showing the genetic similarity of Cornu aspersum mucus between 71 proteins against ~180 related proteins that were found previously in other mollusks. Will-it-slip-or-will-i.jpg
A dendrogram (tree) showing the genetic similarity of Cornu aspersum mucus between 71 proteins against ~180 related proteins that were found previously in other mollusks.

Mucus is a gel consisting of a polymer network that functions as a protective layer for the integument and mucosal surfaces of both elementary animals and mammals. [3]

The mucus of gastropods is not only used as a coating to cover the surfaces on which the snail crawls and a coating to cover the exposed soft parts of the body but also sometimes to allow a resting snail to adhere passively to surfaces, such as rock. [2] Gastropod mucus adhesion uses a temporary sealing structure called the epiphragm. [4] Mucus is produced by a large gland located below the snail's mouth. [5]

The foot of gastropods is covered with a thin layer of this mucus, which is used for a variety of functions, including locomotion, adherence, lubrication, repulsing predators, recognizing other snails, following a trail to a known destination and during reproduction. The discharge looks like a gel and it contains approximately 91 to 98% water by weight, depending on the species, combined with a small amount of high molecular weight glycoproteins (Denny, 1984). In Cornu aspersum, these glycoproteins reach weights of 82, 97 and 175 kDa.

The common garden snail Cornu aspersum Cornu aspersum (Segrijnslak).jpg
The common garden snail Cornu aspersum

Locomotion

Locomotion in snails comes from a series of muscle contractions called pedal waves and relaxations called inter waves. [6] The waves created help propel the snail forward whilst pushing the thin layer of mucus used as lubrication, behind them. In an Experimental Biology article, research has been presented showing that each wave is indeed creating a propulsive force using the mucus to reduce resistance.

Land mollusks travel by adhesive locomotion via muscular waves that propagate from tail to head. The snail mucus has an adapted flow behavior that allows transmittance of the muscular force while maintaining adhesion. [7] [8] When inactive, many mollusks of both marine and terrestrial species, use the secretion to stick to various surfaces. However, although it is so diluted that it can commonly act as a lubricant, it can also have strong adhesive properties. [9] In their unique mating ritual, Limax maximus use a mucus thread to suspend themselves from elevated locations like tree branches. [8] In Cornu aspersum, there are three types of secretion. One type is translucent and not adhesive, the kind that the snail leaves behind as it moves (the slime trail), another is similar but thicker, condensed, more viscous and elastic, which is used to adhere to various surfaces, and a third viscous coating on the dorsal surface that is a protective barrier. [2] Both are clearly differentiated by the type of proteins present in them. [10]

Slime Production

A snail releases different kinds of mucus depending on the way it is stimulated. When the stimulation is normal, the slime is viscous (sticky) but if the snail is disturbed continuously or even violently, it releases clear foamy secretions. If the snail is sexually aroused the slime it releases is clear and viscous (sticky). In the case of Cornu aspersum , the discharge is composed of synthesized products from various types of secretory glands. These are all single-cell glands found in connective tissue and they secrete their products via pores that pass between the epidermal cells. They are of various shapes and usually have a long excretory duct. There are eight different types of secreting glands. Four of these different types secrete protein, calcium, pigments and lipids. [11]

Medical Uses

Some of the characteristics of snail slime have shown to be useful in Chinese medicine. Traditional Chinese medicine has used slime in a variety of ways to treat a variety of illness and cosmetic issues. "For examples, snail powders can treat urinary obstruction by putting them above navel, can prevent nosebleed by blowing the powders into nostrils, can cure deaf by dropping snail powers/wine solution into the ears, can soothe toothache and laryngeal diseases. Furthermore the snail solution obtained by putting snails in water or wine can be used for curing hemorrhoids, boils, scrofulous, scars, and acne. It has also been used as skin creams for wrinkles and dry skin in cosmetics." [12] The Chinese also have used the color-fast dry qualities of snail slime as a natural dye that represented wealth and power. The mucus has shown to be proficient in several biological activities including antimicrobial, antioxidant, anti-tyrosinase, and anti-tumoral activities. [13]

A new generation of tissue adhesive has been developed by using natural adhesion phenomena and mechanisms, such as snail mucus gel, which exhibits excellent haemostatic activity, biocompatibility, and biodegradibility. It is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. [14]

The slime trail is so thick that the animal is able to cross a sharp blade without harm. Helix pomatia on razor blade.jpg
The slime trail is so thick that the animal is able to cross a sharp blade without harm.

See also

Related Research Articles

<span class="mw-page-title-main">Snail</span> Shelled gastropod

A snail is a shelled gastropod. The name is most often applied to land snails, terrestrial pulmonate gastropod molluscs. However, the common name snail is also used for most of the members of the molluscan class Gastropoda that have a coiled shell that is large enough for the animal to retract completely into. When the word "snail" is used in this most general sense, it includes not just land snails but also numerous species of sea snails and freshwater snails. Gastropods that naturally lack a shell, or have only an internal shell, are mostly called slugs, and land snails that have only a very small shell are often called semi-slugs.

<span class="mw-page-title-main">Mucus</span> Secretion produced by mucous membranes

Mucus is a slippery aqueous secretion produced by, and covering, mucous membranes. It is typically produced from cells found in mucous glands, although it may also originate from mixed glands, which contain both serous and mucous cells. It is a viscous colloid containing inorganic salts, antimicrobial enzymes, immunoglobulins, and glycoproteins such as lactoferrin and mucins, which are produced by goblet cells in the mucous membranes and submucosal glands. Mucus serves to protect epithelial cells in the linings of the respiratory, digestive, and urogenital systems, and structures in the visual and auditory systems from pathogenic fungi, bacteria and viruses. Most of the mucus in the body is produced in the gastrointestinal tract.

<span class="mw-page-title-main">Mucin</span> Glycoprotein

Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. They often take an inhibitory role. Some mucins are associated with controlling mineralization, including nacre formation in mollusks, calcification in echinoderms and bone formation in vertebrates. They bind to pathogens as part of the immune system. Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer.

Slime may refer to:

Inspissation is the process of increasing the viscosity of a fluid, or even of causing it to solidify, typically by dehydration or otherwise reducing its content of solvents. The term also has been applied to coagulation by heating of some substances such as albumens, or cooling some such as solutions of gelatin or agar. Some forms of inspissation may be reversed by re-introducing solvent, such as by adding water to molasses or gum arabic; in other forms, its resistance to flow may include cross-linking or mutual adhesion of its component particles or molecules, in ways that prevent their dissolving again, such as in the irreversible setting or gelling of some kinds of rubber latex, egg-white, adhesives, or coagulation of blood.

<i>Cornu aspersum</i> Species of edible land snail

Cornu aspersum, known by the common name garden snail, is a species of land snail in the family Helicidae, which includes some of the most familiar land snails. Of all terrestrial molluscs, this species may well be the most widely known. It was classified under the name Helix aspersa for over two centuries, but the prevailing classification now places it in the genus Cornu.

<span class="mw-page-title-main">Epiphragm</span>

An epiphragm is a temporary structure which can be created by many species of shelled, air-breathing land snails, terrestrial pulmonate gastropod mollusks. It can also be created by freshwater snails when temporary pools dry up.

<span class="mw-page-title-main">Helicidae</span> Family of gastropods

Helicidae is a large, diverse family of western Palaearctic, medium to large-sized, air-breathing land snails, sometimes called the "typical snails." It includes some of the largest European land snails, several species are common in anthropogenic habitats, and some became invasive on other continents. A number of species in this family are valued as food items, including Cornu aspersum the brown or garden snail, and Helix pomatia. The biologies of these two species in particular have been thoroughly studied and documented.

Bioadhesives are natural polymeric materials that act as adhesives. The term is sometimes used more loosely to describe a glue formed synthetically from biological monomers such as sugars, or to mean a synthetic material designed to adhere to biological tissue.

<span class="mw-page-title-main">Land snail</span> Common name for many species of snail

A land snail is any of the numerous species of snail that live on land, as opposed to the sea snails and freshwater snails. Land snail is the common name for terrestrial gastropod mollusks that have shells. However, it is not always easy to say which species are terrestrial, because some are more or less amphibious between land and fresh water, and others are relatively amphibious between land and salt water.

<span class="mw-page-title-main">Foveolar cell</span> Mucus-producing cells in stomach lining protective against gastric acid

Foveolar cells or surface mucouscells are mucus-producing cells which cover the inside of the stomach, protecting it from the corrosive nature of gastric acid. These cells line the gastric mucosa. The mucus-secreting cells of the stomach can be distinguished histologically from the intestinal goblet cells, another type of mucus-secreting cell.

<span class="mw-page-title-main">Slug</span> Shell-less terrestrial gastropod mollusc

Slug, or land slug, is a common name for any apparently shell-less terrestrial gastropod mollusc. The word slug is also often used as part of the common name of any gastropod mollusc that has no shell, a very reduced shell, or only a small internal shell, particularly sea slugs and semi-slugs.

<span class="mw-page-title-main">Love dart</span> Darts that some snails shoot into each other during mating

A love dart is a sharp, calcareous or chitinous dart which some hermaphroditic land snails and slugs create. Love darts are both formed and stored internally in a dart sac. These darts are made in sexually mature animals only, and are used as part of the sequence of events during courtship, before actual mating takes place. Darts are quite large compared to the size of the animal: in the case of the semi-slug genus Parmarion, the length of a dart can be up to one fifth that of the semi-slug's foot.

Mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane. Mucous membranes adhere to epithelial surfaces such as the gastrointestinal tract (GI-tract), the vagina, the lung, the eye, etc. They are generally hydrophilic as they contain many hydrogen macromolecules due to the large amount of water within its composition. However, mucin also contains glycoproteins that enable the formation of a gel-like substance. Understanding the hydrophilic bonding and adhesion mechanisms of mucus to biological material is of utmost importance in order to produce the most efficient applications. For example, in drug delivery systems, the mucus layer must be penetrated in order to effectively transport micro- or nanosized drug particles into the body. Bioadhesion is the mechanism by which two biological materials are held together by interfacial forces. The mucoadhesive properties of polymers can be evaluated via rheological synergism studies with freshly isolated mucus, tensile studies and mucosal residence time studies. Results obtained with these in vitro methods show a high correlation with results obtained in humans.

<span class="mw-page-title-main">Amoeboid movement</span> Mode of locomotion in eukaryotic cells

Amoeboid movement is the most typical mode of locomotion in adherent eukaryotic cells. It is a crawling-like type of movement accomplished by protrusion of cytoplasm of the cell involving the formation of pseudopodia ("false-feet") and posterior uropods. One or more pseudopodia may be produced at a time depending on the organism, but all amoeboid movement is characterized by the movement of organisms with an amorphous form that possess no set motility structures.

<span class="mw-page-title-main">Reproductive system of gastropods</span>

The reproductive system of gastropods varies greatly from one group to another within this very large and diverse taxonomic class of animals. Their reproductive strategies also vary greatly, see mating of gastropods.

<span class="mw-page-title-main">Bovine submaxillary mucin coatings</span> Surface treatment for biomaterials

Bovine submaxillary mucin (BSM) coatings are a surface treatment provided to biomaterials intended to reduce the growth of disadvantageous bacteria and fungi such as S. epidermidis, E. coli, and Candida albicans. BSM is a substance extracted from the fresh salivary glands of cows. It exhibits unique physical properties, such as high molecular weight and amphiphilicity, that allow it to be used for many biomedical applications.

<span class="mw-page-title-main">Arthropod adhesion</span>

Arthropods, including insects and spiders, make use of smooth adhesive pads as well as hairy pads for climbing and locomotion along non-horizontal surfaces. Both types of pads in insects make use of liquid secretions and are considered 'wet'. Dry adhesive mechanisms primarily rely on Van der Waals' forces and are also used by organisms other than insects. The fluid provides capillary and viscous adhesion and appears to be present in all insect adhesive pads. Little is known about the chemical properties of the adhesive fluids and the ultrastructure of the fluid-producing cells is currently not extensively studied. Additionally, both hairy and smooth types of adhesion have evolved separately numerous times in insects. Few comparative studies between the two types of adhesion mechanisms have been done and there is a lack of information regarding the forces that can be supported by these systems in insects. Additionally, tree frogs and some mammals such as the arboreal possum and bats also make use of smooth adhesive pads. The use of adhesive pads for locomotion across non-horizontal surfaces is a trait that evolved separately in different species, making it an example of convergent evolution. The power of adhesion allows these organisms to be able to climb on almost any substance.

Laonidae is a family of small marine snails belonging to the superfamily Philinoidea, though Laonidae and Philinoidea are genetically distinct. They are monophyletic, meaning they are developed from a single ancestor. Laonidae also has the synonymised name Laoninae, which is largely unaccepted in the modern day scientific community. The name Laoninae is introduced by Alice Pruvot-Fol who proposes it as the subfamily to the genea Loana, A.Adams 1865.

<span class="mw-page-title-main">Slime coat</span> Fish integument

The slime coat is the coating of mucus covering the body of all fish. An important part of fish anatomy, it serves many functions, depending on species, ranging from locomotion, care and feeding of offspring, to resistance to disease and parasites.

References

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<ref>Yu, Dan-Ni; Tian, Dan; He, Ji-Huan (2018-06-01). "Snail-based nanofibers". Materials Letters. 220: 5–7. https://www.sciencedirect.com/science/article/abs/pii/S0167577X18302908?via%3Dihub

<ref>Noothuan, N., Apitanyasai, K., Panha, S. et al. Snail mucus from the mantle and foot of two land snails, Lissachatina fulica and Hemiplecta distincta, exhibits different protein profile and biological activity. BMC Res Notes 14, 138 (2021). https://doi.org/10.1186/s13104-021-05557-0