Sodium- and chloride-dependent taurine transporter

SLC6A6
Identifiers
Aliases	SLC6A6 , TAUT, solute carrier family 6 member 6, HTRDC
External IDs	OMIM: 186854 MGI: 98488 HomoloGene: 2291 GeneCards: SLC6A6
Gene location (Human)
Chr.	Chromosome 3 (human)
End	14,489,349 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	91,759,066 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; blood; ; visceral pleura; ; bronchial epithelial cell; ; monocyte; ; germinal epithelium; ; secondary oocyte; ; parietal pleura; ; adrenal cortex; ; right lung;
	Top expressed in
	ciliary body; ; iris; ; calvaria; ; retinal pigment epithelium; ; ankle joint; ; ankle; ; lip; ; adrenal gland; ; external carotid artery; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	neurotransmitter:sodium symporter activity ; symporter activity ; amino acid transmembrane transporter activity ; taurine:sodium symporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	cellular amino acid metabolic process ; amino acid transmembrane transport ; neurotransmitter transport ; amino acid transport ; taurine transport ; transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	6533
	21366
	ENSG00000131389
	ENSMUSG00000030096
	P31641
	O35316
	NM_001134367 ; NM_001134368 ; NM_003043
	NM_009320
	NP_001127839 ; NP_001127840 ; NP_003034
	NP_033346
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131389 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030096 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V (Jul 1994). "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta". Biochem J. 300 (3): 893–900. doi:10.1042/bj3000893. PMC 1138249 . PMID 8010975.
↑ Jhiang SM, Fithian L, Smanik P, McGill J, Tong Q, Mazzaferri EL (Mar 1993). "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells". FEBS Lett. 318 (2): 139–44. doi:10.1016/0014-5793(93)80008-I. PMID 8382624. S2CID 28368668.
↑ "Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6".

Uchida S, Kwon HM, Yamauchi A, et al. (1992). "Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(−)-dependent taurine transporter that is regulated by hypertonicity". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8230–4. Bibcode:1992PNAS...89.8230U. doi: 10.1073/pnas.89.17.8230 . PMC 49891 . PMID 1518851.
Miyamoto Y, Liou GI, Sprinkle TJ (1996). "Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium". Curr. Eye Res. 15 (3): 345–9. doi:10.3109/02713689609007631. PMID 8654117.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Mochizuki T, Satsu H, Shimizu M (2002). "Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells". FEBS Lett. 517 (1–3): 92–6. doi: 10.1016/S0014-5793(02)02584-X . PMID 12062416. S2CID 86171679.
Han X, Patters AB, Chesney RW (2002). "Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells". J. Biol. Chem. 277 (42): 39266–73. doi: 10.1074/jbc.M205939200 . PMID 12163498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Han X, Chesney RW (2003). "Regulation of taurine transporter gene (TauT) by WT1". FEBS Lett. 540 (1–3): 71–6. doi:10.1016/S0014-5793(03)00227-8. PMID 12681485. S2CID 32139788.
Roos S, Powell TL, Jansson T (2004). "Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation". Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (4): R886–93. CiteSeerX 10.1.1.1026.3853 . doi:10.1152/ajpregu.00232.2004. PMID 15166008.
Satsu H, Manabe M, Shimizu M (2004). "Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter". FEBS Lett. 569 (1–3): 123–8. doi: 10.1016/j.febslet.2004.05.062 . PMID 15225620. S2CID 11395494.
Mochizuki T, Satsu H, Nakano T, Shimizu M (2005). "Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells". BioFactors. 21 (1–4): 141–4. doi:10.1002/biof.552210128. PMID 15630186. S2CID 35504141.
Mochizuki T, Satsu H, Shimizu M (2005). "Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells". FEBS Lett. 579 (14): 3069–74. doi: 10.1016/j.febslet.2005.04.063 . PMID 15907840. S2CID 84235462.
Nakashima E, Pop-Busui R, Towns R, et al. (2006). "Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase" (PDF). Antioxid. Redox Signal. 7 (11–12): 1530–42. doi:10.1089/ars.2005.7.1530. hdl: 2027.42/63284 . PMID 16356117.
Iruloh CG, D'Souza SW, Speake PF, et al. (2007). "Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity". Am. J. Physiol., Cell Physiol. 292 (1): C332–41. doi:10.1152/ajpcell.00634.2005. PMID 16956961.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131389 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030096 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8010975-5] Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V (Jul 1994). "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta". Biochem J. 300 (3): 893–900. doi:10.1042/bj3000893. PMC 1138249 . PMID 8010975.

[pmid8382624-6] Jhiang SM, Fithian L, Smanik P, McGill J, Tong Q, Mazzaferri EL (Mar 1993). "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells". FEBS Lett. 318 (2): 139–44. doi:10.1016/0014-5793(93)80008-I. PMID 8382624. S2CID 28368668.

[entrez-7] "Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6".

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Sodium- and chloride-dependent taurine transporter

Related Research Articles

References

Further reading