Solute carrier family 10 member 4

SLC10A4
Identifiers
Aliases	SLC10A4 , P4, solute carrier family 10 member 4
External IDs	MGI: 3606480 HomoloGene: 15495 GeneCards: SLC10A4
Gene location (Human)
Chr.	Chromosome 4 (human)
End	48,489,526 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	73,170,298 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; superior vestibular nucleus; ; anterior pituitary; ; endothelial cell; ; prefrontal cortex; ; hypothalamus; ; putamen; ; ganglionic eminence; ; dorsolateral prefrontal cortex; ; caudate nucleus;
	Top expressed in
	neural tube; ; morula; ; anterior horn of spinal cord; ; mesencephalon; ; adrenal gland; ; superior frontal gyrus; ; rhombencephalon; ; autonomic nervous system; ; pons; ; trigeminal nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	symporter activity ; bile acid:sodium symporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; membrane ; integral component of synaptic vesicle membrane ; dopaminergic synapse ; cholinergic synapse ; serotonergic synapse ;
Biological process	ion transport ; transmembrane transport ; sodium ion transport ; bile acid and bile salt transport ; adult behavior ; regulation of neurotransmitter loading into synaptic vesicle ;
	Sources:Amigo / QuickGO
Orthologs
	201780
	231290
	ENSG00000145248
	ENSMUSG00000029219
	Q96EP9
	Q3UEZ8
	NM_152679
	NM_173403
	NP_689892
	NP_775579
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 08, 2023

Solute carrier family 10 member 4 is a protein that in humans is encoded by the SLC10A4 gene.^[5] In mice, it appears to promote acidification of synaptic vesicles containing monoamines, enhancing their uptake, and is co-expressed with VMAT2 and VAChT.^[6]

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SLC45A1 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, such as glucose and sucrose (ii) perform secondary active transport in a proton-dependent manner.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145248 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029219 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Solute carrier family 10 member 4" . Retrieved 2016-04-17.
↑ Larhammar M, Patra K, Blunder M, Emilsson L, Peuckert C, Arvidsson E, Rönnlund D, Preobraschenski J, Birgner C, Limbach C, Widengren J, Blom H, Jahn R, Wallén-Mackenzie Å, Kullander K (March 2015). "SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis". Biological Psychiatry. 77 (6): 526–36. doi:10.1016/j.biopsych.2014.07.017. hdl: 11858/00-001M-0000-0025-7742-E . PMID 25176177. S2CID 6665524.

Solute carrier family 10 member 4

Related Research Articles

References

Further reading