Solute carrier organic anion transporter family member 4c1

SLCO4C1
Identifiers
Aliases	SLCO4C1 , OATP-H, OATP-M1, OATP4C1, OATPX, PRO2176, SLC21A20, solute carrier organic anion transporter family member 4C1
External IDs	OMIM: 609013 MGI: 2442784 HomoloGene: 62654 GeneCards: SLCO4C1
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q21.1 Start 102,233,986 bp [1] End 102,296,284 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 96,743,995 bp [2] End 96,799,896 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule palpebral conjunctiva renal medulla lower lobe of lung glomerulus metanephric glomerulus kidney bronchial epithelial cell bone marrow spongy bone Top expressed in seminal vesicula left lung lobe prostate olfactory epithelium lacrimal gland yolk sac conjunctival fornix morula proximal straight tubule right lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of membrane plasma membrane basolateral plasma membrane extracellular exosome membrane azurophil granule membrane specific granule membrane integral component of plasma membrane Biological process multicellular organism development cell differentiation ion transport spermatogenesis neutrophil degranulation sodium-independent organic anion transport transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 353189 227394 Ensembl ENSG00000173930 ENSMUSG00000040693 UniProt Q6ZQN7 Q8BGD4 RefSeq (mRNA) NM_180991 NM_172658 RefSeq (protein) NP_851322 NP_766246 Location (UCSC) Chr 5: 102.23 – 102.3 Mb Chr 1: 96.74 – 96.8 Mb PubMed search [3] [4]
Wikidata
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Solute carrier organic anion transporter family member 4C1 is a protein that in humans is encoded by the SLCO4C1 gene, which is located on chromosome 5q21. The OATP4C1 protein is expressed in the basolateral membrane of the nephron of the human kidney, where it is involved in the uptake of organic anions for elimination in the urine. The drug digoxin is an important substrate of this transporter. ^{[5] [6]}

Function

SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).

References

1. GRCh38: Ensembl release 89: ENSG00000173930 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040693 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mikkaichi T, Suzuki T, Onogawa T, et al. (March 2004). "Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3569–74. Bibcode:2004PNAS..101.3569M. doi: 10.1073/pnas.0304987101 . PMC   373503 . PMID   14993604.
6. "Entrez Gene: Solute carrier organic anion transporter family member 4C1" . Retrieved 2016-03-11.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.