Sonrotoclax

Sonrotoclax

Identifiers
IUPAC name N-[4-[(4-hydroxy-4-methylcyclohexyl)methylamino]-3-nitrophenyl]sulfonyl-4-[2-[(2S)-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
CAS Number	2383086-06-2
PubChem CID	149553242
ChemSpider	129309008
UNII	30R67U9KYS
KEGG	D12883
ChEMBL	ChEMBL5314951
Chemical and physical data
Formula	C49H59N7O7S
Molar mass	890.11 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)C1=CC=CC=C1[C@@H]2CCCN2C3CC4(C3)CCN(CC4)C5=CC(=C(C=C5)C(=O)NS(=O)(=O)C6=CC(=C(C=C6)NCC7CCC(CC7)(C)O)[N+](=O)[O-])OC8=CN=C9C(=C8)C=CN9
InChI InChI=InChI=1S/C49H59N7O7S/c1-32(2)39-7-4-5-8-40(39)43-9-6-22-55(43)36-28-49(29-36)19-23-54(24-20-49)35-10-12-41(45(26-35)63-37-25-34-16-21-50-46(34)52-31-37)47(57)53-64(61,62)38-11-13-42(44(27-38)56(59)60)51-30-33-14-17-48(3,58)18-15-33/h4-5,7-8,10-13,16,21,25-27,31-33,36,43,51,58H,6,9,14-15,17-20,22-24,28-30H2,1-3H3,(H,50,52)(H,53,57)/t33?,43-,48?/m0/s1 Key:ZQTKOYMWCCSKON-HCWAPQBJSA-N

Sonrotoclax is an investigational new drug that is being evaluated for the treatment of hematologic malignancies, particularly chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). ^[1] It is a potent and selective BCL2 inhibitor that can overcome resistance associated with BCL2 mutations, such as the G101V variant, which limits the effectiveness of first-generation inhibitors like venetoclax. ^[2]

References

1. "Sonrotoclax - BeiGene". AdisInsight. Springer Nature Switzerland AG.
2. Tomkins O, D'Sa S (2024). "Review of BCL2 inhibitors for the treatment of Waldenström's macroglobulinaemia and non-IgM lymphoplasmacytic lymphoma". Frontiers in Oncology. 14: 1490202. doi: 10.3389/fonc.2024.1490202 . PMC   11570586 . PMID   39558954.