U.S. Route 14 or U.S. Highway 14 (US 14), an east–west route, is one of the original United States Numbered Highways of 1926. It currently has a length of about 1,445 miles (2,326 km), for much of which it runs roughly parallel to Interstate 90 (I-90).
U.S. Route 77 is a major north–south United States Numbered Highway which extends for 1,305 miles (2,100 km) in the central United States. As of 2005, Its southern terminus is in Brownsville, Texas, at Veteran's International Bridge on the Mexican border, where it connects with both Mexican Federal Highway 101 and Mexican Federal Highway 180, and the highway's northern terminus is in Sioux City, Iowa, at an interchange with Interstate 29 (I-29), less than 1⁄2 mile (800 m) north of the Nebraska state line.
U.S. Route 81 or U.S. Highway 81 (US 81) is a major north–south U.S. highway that extends for 1,220 miles (1,960 km) in the central United States and is one of the original United States Numbered Highways established in 1926 by the American Association of State Highway Officials.
U.S. Route 83 (US 83) is a major north–south United States Numbered Highway that extends 1,885 miles (3,034 km) in the central United States. Only four other north–south routes are longer: US 1, US 41, US 59, and US 87, while US 83 follows a straighter north-south path than all of these. Nearly half of its mileage is in the state of Texas. The highway's northern terminus is north of Westhope, North Dakota, at the Canadian border, where it continues as Manitoba Highway 83 (PTH 83). The southern terminus is at the Veterans International Bridge in Brownsville, Texas. Together, US 83 and PTH 83 form a continuously numbered north-south highway with a combined distance of 3,450 kilometres (2,140 mi).
U.S. Route 183 (US 183) is a north–south United States highway. The highway's northern terminus is in Presho, South Dakota, at an intersection with Interstate 90. Its southern terminus is in Refugio, Texas, at the southern intersection of U.S. Highway 77 and Alternate US 77.
U.S. Highway 16 (US 16) is an east–west United States Numbered Highway between Rapid City, South Dakota, and Yellowstone National Park in Wyoming. The highway's eastern terminus is at a junction with Interstate 90 (I-90)/US 14, concurrent with I-190, in Rapid City. The western terminus is the east entrance to Yellowstone National Park, concurrent with US 14 and US 20. US 16 used to extend all the way to Michigan but has been truncated in favor of I-90 and I-96.
South Dakota Highway 43 (SD 43) is a 1.131-mile-long (1.820 km) state highway that exists entirely in the southern part of Gregory County in the southern part of the U.S. state of South Dakota. It begins as an extension of Nebraska Highway 11 (N-11) at the Nebraska state line south of Fairfax. It travels northwest to an intersection with U.S. Route 18 (US 18) south-southwest of the town.
South Dakota Highway 45 is a state highway that runs north to south across much of central South Dakota, United States. The northern terminus is at the North Dakota border as a continuation of North Dakota Highway 3, and runs south to South Dakota Highway 44 at Platte. It is 198 miles (319 km) in length.
South Dakota Highway 47 is a state route that runs north to south across the central portion of South Dakota. It begins at an unnumbered highway at the North Dakota border north of Eureka, and ends at the Nebraska border, where it becomes Nebraska Highway 137. It is just under 241 miles (388 km) in length.
South Dakota Highway 52 is a state route that runs just north of the Missouri River, across southeast South Dakota. It begins at a junction with South Dakota Highway 37 north of Springfield, and terminates in Yankton at U.S. Highway 81, at the junction of 4th and Broadway Streets. It is 37 miles (60 km) in length.
South Dakota Highway 15 (SD 15) is a 67.562-mile-long (108.730 km) state highway in the northeastern South Dakota, United States. It connects Clear Lake, Milbank, and Wilmot.
South Dakota Highway 50 is a state route serving south central and southeast South Dakota. The current alignment begins at the junction of South Dakota Highway 34 at "Lee's Corner" east of Fort Thompson, and ends at the Iowa border near Richland, where it continues as Iowa Highway 3. It is about 212 miles (341 km) in length.
South Dakota Highway 75 is a state route located in northwest South Dakota. The southern terminus is at South Dakota Highway 20 west of Bison, and the route runs northerly to the North Dakota border, becoming North Dakota Highway 8. It is 28 miles in length.
South Dakota Highway 34 is a state route that runs parallel to Interstate 90 across the entire state of South Dakota. It begins at the Wyoming border west of Belle Fourche, as a continuation of Wyoming Highway 24 (WYO 24). The eastern terminus is at the Minnesota border east of Egan, or southwest of Airlie, Minnesota, where it continues as Minnesota State Highway 30 (MN 30). It is just over 419 miles (674 km) in length, making it the longest state highway in South Dakota.
South Dakota Highway 65 is a state route in north-central region of the U.S. state of South Dakota. It begins at U.S. Highway 212 east of Dupree, then runs northerly to the North Dakota border near McIntosh, where it continues as North Dakota Highway 31. It is about 68 miles (109 km) in length.
South Dakota Highway 73 is a state route that runs across western South Dakota. It begins at the Nebraska border north of Merriman, Nebraska, as a continuation of Nebraska Highway 61. It runs to the North Dakota border, where it continues as North Dakota Highway 49. It is just more than 255 miles (410 km) in length.
South Dakota Highway 37 is a state route that runs across eastern South Dakota. It begins at the Nebraska border northeast of Niobrara, Nebraska, as a continuation of Nebraska Highway 14. It runs to the North Dakota border north of Hecla, where it continues as North Dakota Highway 1. It is 242 miles (389 km) in length.
State Highway 71 is a 224-mile-long (360 km) state highway passing several other highways in northern and central Colorado. SH 71's southern terminus is at U.S. Route 350 near La Junta, and the northern terminus is a continuation as Nebraska Highway 71 (N-71) at the Nebraska border, which eventually crosses into South Dakota as South Dakota Highway 71 (SD-71), making Highway 71 a triple-state highway.
U.S. Route 183 (US-183) is a part of the U.S. Highway System that runs from US-77 in Refugio, Texas north to Interstate 90 (I-90) in Presho, South Dakota. In the U.S. state of Kansas, US-183 is a main north–south highway that runs from the Oklahoma border north to the Nebraska border.
US 18 west of Winner 
SD 44 east of Wood 
I-90 / US 83 in Vivian 
