SPAG11B | |||||||||||||||||||||||||
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Aliases | SPAG11B , EDDM2B, EP2, EP2C, EP2D, HE2, HE2C, SPAG11, sperm associated antigen 11B, SPAG11A | ||||||||||||||||||||||||
External IDs | OMIM: 606560 MGI: 3647173 HomoloGene: 83383 GeneCards: SPAG11B | ||||||||||||||||||||||||
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Species | Human | Mouse | |||||||||||||||||||||||
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | Chr 8: 7.44 – 7.46 Mb | Chr 8: 19.19 – 19.19 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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Sperm-associated antigen 11B is a protein that in humans is encoded by the SPAG11B gene. [5] [6] [7]
This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [7]
Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.
Nuclear autoantigenic sperm protein is a protein that in humans is encoded by the NASP gene. Multiple isoforms are encoded by transcript variants of this gene.
C-jun-amino-terminal kinase-interacting protein 4 is a scaffold protein that in humans is encoded by the SPAG9 gene.
WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene.
Sperm-associated antigen 6 is a protein that in humans is encoded by the SPAG6 gene.
A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.
Sperm-associated antigen 1 is a protein that in humans is encoded by the SPAG1 gene.
Cystatin-8 is a protein that in humans is encoded by the CST8 gene.
Acrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene.
Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene.
A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene. It involves in the intracellular signalling of protein kinase -A. AKAP4 is called as cancer /testis antigen (CTA), it belongs to a class of tumour linked antigens categories by high expression in germ cells and cancer than normal tissues. AKAP4 is not normally expressed in mRNA and protein level in MM cell line.
Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized.
Cysteine-rich secretory protein 1 is a cysteine-rich secretory protein that in humans is encoded by the CRISP1 gene.
UDP-N-acetylhexosamine pyrophosphorylase is an enzyme that in humans is encoded by the UAP1 gene.
Sperm flagellar protein 2 is a protein that in humans is encoded by the SPEF2 gene.
Beta-defensin 118 is a protein that in humans is encoded by the DEFB118 gene.
Eppin is a protein that in humans is encoded by the SPINLW1 gene.
Beta-defensin 126 is a protein that in humans is encoded by the DEFB126 gene.
Sperm-associated antigen 7 is a protein that in humans is encoded by the SPAG7 gene.
Disintegrin and metalloproteinase domain-containing protein 7 is a protein that in humans is encoded by the ADAM7 gene. ADAM7 is an 85-kDa enzyme that is a member of the transmembrane ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM7 is important for the maturation of sperm cells in mammals. ADAM7 is also denoted as: ADAM_7, ADAM-7, EAPI, GP-83, and GP83.