Sperm-associated antigen 5

SPAG5
Identifiers
Aliases	SPAG5 , DEEPEST, MAP126, hMAP126, Sperm associated antigen 5
External IDs	OMIM: 615562; MGI: 1927470; HomoloGene: 4718; GeneCards: SPAG5; OMA:SPAG5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q11.2 Start 28,577,565 bp [1] End 28,599,025 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 B5|11 46.74 cM Start 78,192,355 bp [2] End 78,213,283 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis ventricular zone gonad ganglionic eminence mucosa of transverse colon testicle right lobe of liver right lobe of thyroid gland human kidney Top expressed in epithelium of lens spermatocyte ventricular zone spermatid tail of embryo lumbar subsegment of spinal cord seminiferous tubule epiblast genital tubercle mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding microtubule binding Cellular component spindle mitotic spindle chromosome microtubule organizing center centriolar satellite spindle pole chromosome, centromeric region microtubule plus-end midbody microtubule kinetochore cytoskeleton cytoplasm mitotic spindle pole spindle microtubule Biological process mitotic sister chromatid segregation cell cycle spindle organization cell division protein localization to centrosome chromosome segregation regulation of attachment of spindle microtubules to kinetochore positive regulation of intracellular transport regulation of metaphase plate congression positive regulation of spindle assembly establishment of spindle orientation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10615 54141 Ensembl ENSG00000076382 ENSMUSG00000002055 UniProt Q96R06 Q7TME2 RefSeq (mRNA) NM_006461 NM_017407 RefSeq (protein) NP_006452 NP_059103 Location (UCSC) Chr 17: 28.58 – 28.6 Mb Chr 11: 78.19 – 78.21 Mb PubMed search [3] [4]
Wikidata
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Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene. ^{[5] [6]}

This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000076382 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002055 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chang MS, Huang CJ, Chen ML, Chen ST, Fan CC, Chu JM, Lin WC, Yang YC (Sep 2001). "Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins". Biochem Biophys Res Commun. 287 (1): 116–21. doi:10.1006/bbrc.2001.5554. PMID   11549262.
6. "Entrez Gene: SPAG5 sperm associated antigen 5".

Further reading

• Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi: 10.1074/jbc.274.44.31693 . PMID   10531379.
• Shao X, Xue J, van der Hoorn FA (2001). "Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1". Mol. Reprod. Dev. 59 (4): 410–6. doi: 10.1002/mrd.1047 . PMID   11468777. S2CID   13590694.
• Mack GJ, Compton DA (2002). "Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14434–9. doi: 10.1073/pnas.261371298 . PMC   64699 . PMID   11724960.
• Gruber J, Harborth J, Schnabel J, et al. (2003). "The mitotic-spindle-associated protein astrin is essential for progression through mitosis". J. Cell Sci. 115 (Pt 21): 4053–9. doi: 10.1242/jcs.00088 . hdl: 11858/00-001M-0000-0012-F29B-B . PMID   12356910.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi: 10.1074/jbc.M403080200 . PMID   15504738.
• Yang YC, Hsu YT, Wu CC, et al. (2006). "Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells" (PDF). Biochem. Biophys. Res. Commun. 343 (2): 428–34. doi:10.1016/j.bbrc.2006.02.166. PMID   16546135.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Cheng TS, Hsiao YL, Lin CC, et al. (2007). "hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases" (PDF). Exp. Cell Res. 313 (8): 1710–21. doi:10.1016/j.yexcr.2007.02.023. PMID   17383637.