Stabilizing selection

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1: directional selection: a single extreme phenotype favoured.
2, stabilizing selection: intermediate favoured over extremes.
3: disruptive selection: extremes favoured over intermediate.
X-axis: phenotypic trait
Y-axis: number of organisms
Group A: original population
Group B: after selection Genetic Distribution.svg
1: directional selection: a single extreme phenotype favoured.
2, stabilizing selection: intermediate favoured over extremes.
3: disruptive selection: extremes favoured over intermediate.
X-axis: phenotypic trait
Y-axis: number of organisms
Group A: original population
Group B: after selection

Stabilizing selection (not to be confused with negative or purifying selection [1] [2] ) is a type of natural selection in which the population mean stabilizes on a particular non-extreme trait value. This is thought to be the most common mechanism of action for natural selection because most traits do not appear to change drastically over time. [3] Stabilizing selection commonly uses negative selection (a.k.a. purifying selection) to select against extreme values of the character. Stabilizing selection is the opposite of disruptive selection. Instead of favoring individuals with extreme phenotypes, it favors the intermediate variants. Stabilizing selection tends to remove the more severe phenotypes, resulting in the reproductive success of the norm or average phenotypes. [4] This means that most common phenotype in the population is selected for and continues to dominate in future generations.

Contents

Depending on the environmental conditions, a wolf may have an advantage over wolves with other variations of fur color. Wolves with fur colors that do not camouflage appropriately with the environmental conditions will be spotted more easily by the deer, resulting in them not being able to sneak up on the deer (leading to natural selection). Directional, Disruptive and Stabilizing Selections.svg
Depending on the environmental conditions, a wolf may have an advantage over wolves with other variations of fur color. Wolves with fur colors that do not camouflage appropriately with the environmental conditions will be spotted more easily by the deer, resulting in them not being able to sneak up on the deer (leading to natural selection).

History

The Russian evolutionary biologist Ivan Schmalhausen founded the theory of stabilizing selection, publishing a paper in Russian titled "Stabilizing selection and its place among factors of evolution" in 1941 and a monograph "Factors of Evolution: The Theory of Stabilizing Selection" in 1945. [5] [6]

Influence on population structure

Stabilizing selection causes the narrowing of the phenotypes seen in a population. This is because the extreme phenotypes are selected against, causing reduced survival in organisms with those traits. This results in a population consisting of fewer phenotypes, with most traits representing the mean value of the population. This narrowing of phenotypes causes a reduction in genetic diversity in a population. [7] Maintaining genetic variation is essential for the survival of a population because it is what allows them to evolve over time. In order for a population to adapt to changing environmental conditions they must have enough genetic diversity to select for new traits as they become favorable. [8]

Analyzing stabilizing selection

There are four primary types of data used to quantify stabilizing selection in a population. The first type of data is an estimation of fitness of different phenotypes within a single generation. Quantifying fitness in a single generation creates predictions for the expected fate of selection. The second type of data is changes in allelic frequencies or phenotypes across different generations. This allows quantification of change in prevalence of a certain phenotype, indicating the type of selection. The third type of data is differences in allelic frequencies across space. This compares selection occurring in different populations and environmental conditions. The fourth type of data is DNA sequences from the genes contributing to observes phenotypic differences. The combination of these four types of data allow population studies that can identify the type of selection occurring and quantify the extent of selection. [9]

However, a meta-analysis of studies that measured selection in the wild failed to find an overall trend for stabilizing selection. [10] The reason can be that methods for detecting stabilizing selection are complex. They can involve studying the changes that causes natural selection in the mean and variance of the trait, or measuring fitness for a range of different phenotypes under natural conditions and examining the relationship between these fitness measurements and the trait value, but analysis and interpretation of the results is not straightforward. [11]

Examples

The most common form of stabilizing selection is based on phenotypes of a population. In phenotype based stabilizing selection, the mean value of a phenotype is selected for, resulting a decrease in the phenotypic variation found in a population. [12]

Humans

Stabilizing selection is the most common form of nonlinear selection (non-directional) in humans. [13] There are few examples of genes with direct evidence of stabilizing selection in humans. However, most quantitative traits (height, birthweight, schizophrenia) are thought to be under stabilizing selection, due to their polygenicity and the distribution of the phenotypes throughout human populations. [14]

Plants

Insects

Birds

Mammals

See also

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<span class="mw-page-title-main">Heredity</span> Passing of traits to offspring from the species parents or ancestor

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<span class="mw-page-title-main">Natural selection</span> Mechanism of evolution by differential survival and reproduction of individuals

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<span class="mw-page-title-main">Modern synthesis (20th century)</span> Fusion of natural selection with Mendelian inheritance

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<span class="mw-page-title-main">Sexual dimorphism</span> Condition where males and females exhibit different characteristics

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<span class="mw-page-title-main">Directional selection</span> Type of genetic selection favoring one extreme phenotype

In population genetics, directional selection is a mode of negative natural selection in which an extreme phenotype is favored over other phenotypes, causing the allele frequency to shift over time in the direction of that phenotype. Under directional selection, the advantageous allele increases as a consequence of differences in survival and reproduction among different phenotypes. The increases are independent of the dominance of the allele, and if the allele is recessive, it will eventually become fixed.

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<i>Bicyclus anynana</i> Species of butterfly

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