Stabilizing selection (not to be confused with negative or purifying selection [1] [2] ) is a type of natural selection in which the population mean stabilizes on a particular non-extreme trait value. This is thought to be the most common mechanism of action for natural selection because most traits do not appear to change drastically over time. [3] Stabilizing selection commonly uses negative selection (a.k.a. purifying selection) to select against extreme values of the character. Stabilizing selection is the opposite of disruptive selection. Instead of favoring individuals with extreme phenotypes, it favors the intermediate variants. Stabilizing selection tends to remove the more severe phenotypes, resulting in the reproductive success of the norm or average phenotypes. [4] This means that most common phenotype in the population is selected for and continues to dominate in future generations.
The Russian evolutionary biologist Ivan Schmalhausen founded the theory of stabilizing selection, publishing a paper in Russian titled "Stabilizing selection and its place among factors of evolution" in 1941 and a monograph "Factors of Evolution: The Theory of Stabilizing Selection" in 1945. [5] [6]
Stabilizing selection causes the narrowing of the phenotypes seen in a population. This is because the extreme phenotypes are selected against, causing reduced survival in organisms with those traits. This results in a population consisting of fewer phenotypes, with most traits representing the mean value of the population. This narrowing of phenotypes causes a reduction in genetic diversity in a population. [7] Maintaining genetic variation is essential for the survival of a population because it is what allows them to evolve over time. In order for a population to adapt to changing environmental conditions they must have enough genetic diversity to select for new traits as they become favorable. [8]
There are four primary types of data used to quantify stabilizing selection in a population. The first type of data is an estimation of fitness of different phenotypes within a single generation. Quantifying fitness in a single generation creates predictions for the expected fate of selection. The second type of data is changes in allelic frequencies or phenotypes across different generations. This allows quantification of change in prevalence of a certain phenotype, indicating the type of selection. The third type of data is differences in allelic frequencies across space. This compares selection occurring in different populations and environmental conditions. The fourth type of data is DNA sequences from the genes contributing to observes phenotypic differences. The combination of these four types of data allow population studies that can identify the type of selection occurring and quantify the extent of selection. [9]
However, a meta-analysis of studies that measured selection in the wild failed to find an overall trend for stabilizing selection. [10] The reason can be that methods for detecting stabilizing selection are complex. They can involve studying the changes that causes natural selection in the mean and variance of the trait, or measuring fitness for a range of different phenotypes under natural conditions and examining the relationship between these fitness measurements and the trait value, but analysis and interpretation of the results is not straightforward. [11]
The most common form of stabilizing selection is based on phenotypes of a population. In phenotype based stabilizing selection, the mean value of a phenotype is selected for, resulting a decrease in the phenotypic variation found in a population. [12]
Stabilizing selection is the most common form of nonlinear selection (non-directional) in humans. [13] There are few examples of genes with direct evidence of stabilizing selection in humans. However, most quantitative traits (height, birthweight, schizophrenia) are thought to be under stabilizing selection, due to their polygenicity and the distribution of the phenotypes throughout human populations. [14]
Evolution is the change in the heritable characteristics of biological populations over successive generations. It occurs when evolutionary processes such as natural selection and genetic drift act on genetic variation, resulting in certain characteristics becoming more or less common within a population over successive generations. The process of evolution has given rise to biodiversity at every level of biological organisation.
Heredity, also called inheritance or biological inheritance, is the passing on of traits from parents to their offspring; either through asexual reproduction or sexual reproduction, the offspring cells or organisms acquire the genetic information of their parents. Through heredity, variations between individuals can accumulate and cause species to evolve by natural selection. The study of heredity in biology is genetics.
Natural selection is the differential survival and reproduction of individuals due to differences in phenotype. It is a key mechanism of evolution, the change in the heritable traits characteristic of a population over generations. Charles Darwin popularised the term "natural selection", contrasting it with artificial selection, which is intentional, whereas natural selection is not.
Population genetics is a subfield of genetics that deals with genetic differences within and among populations, and is a part of evolutionary biology. Studies in this branch of biology examine such phenomena as adaptation, speciation, and population structure.
Ecological genetics is the study of genetics in natural populations. It combines ecology, evolution, and genetics to understand the processes behind adaptation. It is virtually synonymous with the field of molecular ecology.
In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species. To be classified as such, morphs must occupy the same habitat at the same time and belong to a panmictic population.
In population genetics, directional selection is a type of natural selection in which one extreme phenotype is favored over both the other extreme and moderate phenotypes. This genetic selection causes the allele frequency to shift toward the chosen extreme over time as allele ratios change from generation to generation. The advantageous extreme allele will increase as a consequence of survival and reproduction differences among the different present phenotypes in the population. The allele fluctuations as a result of directional selection can be independent of the dominance of the allele, and in some cases if the allele is recessive, it can eventually become fixed in the population.
This is a list of topics in evolutionary biology.
In biology, adaptation has three related meanings. Firstly, it is the dynamic evolutionary process of natural selection that fits organisms to their environment, enhancing their evolutionary fitness. Secondly, it is a state reached by the population during that process. Thirdly, it is a phenotypic trait or adaptive trait, with a functional role in each individual organism, that is maintained and has evolved through natural selection.
In evolutionary biology, disruptive selection, also called diversifying selection, describes changes in population genetics in which extreme values for a trait are favored over intermediate values. In this case, the variance of the trait increases and the population is divided into two distinct groups. In this more individuals acquire peripheral character value at both ends of the distribution curve.
Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene. Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function.
Anisogamy is a form of sexual reproduction that involves the union or fusion of two gametes that differ in size and/or form. The smaller gamete is male, a sperm cell, whereas the larger gamete is female, typically an egg cell. Anisogamy is predominant among multicellular organisms. In both plants and animals, gamete size difference is the fundamental difference between females and males.
The domestication of vertebrates is the mutual relationship between vertebrate animals including birds and mammals, and the humans who have influence on their care and reproduction.
The theory of facilitated variation demonstrates how seemingly complex biological systems can arise through a limited number of regulatory genetic changes, through the differential re-use of pre-existing developmental components. The theory was presented in 2005 by Marc W. Kirschner and John C. Gerhart.
Sex-limited genes are genes that are present in both sexes of sexually reproducing species but are expressed in only one sex and have no penetrance, or are simply 'turned off' in the other. In other words, sex-limited genes cause the two sexes to show different traits or phenotypes, despite having the same genotype. This term is restricted to autosomal traits, and should not be confused with sex-linked characteristics, which have to do with genetic differences on the sex chromosomes. Sex-limited genes are also distinguished from sex-influenced genes, where the same gene will show differential expression in each sex. Sex-influenced genes commonly show a dominant/recessive relationship, where the same gene will have a dominant effect in one sex and a recessive effect in the other. However, the resulting phenotypes caused by sex-limited genes are present in only one sex and can be seen prominently in various species that typically show high sexual dimorphism.
Bicyclus anynana is a small brown butterfly in the family Nymphalidae, the most globally diverse family of butterflies. It is primarily found in eastern Africa from southern Sudan to Eswatini. It is found mostly in woodland areas and flies close to the ground. Male wingspans are 35–40 mm and female wingspans are 45–49 mm.
Recurrent evolution also referred to as repeated or replicated evolution is the repeated evolution of a particular trait, character, or mutation. Most evolution is the result of drift, often interpreted as the random chance of some alleles being passed down to the next generation and others not. Recurrent evolution is said to occur when patterns emerge from this stochastic process when looking across multiple distinct populations. These patterns are of particular interest to evolutionary biologists, as they can demonstrate the underlying forces governing evolution.
This glossary of genetics and evolutionary biology is a list of definitions of terms and concepts used in the study of genetics and evolutionary biology, as well as sub-disciplines and related fields, with an emphasis on classical genetics, quantitative genetics, population biology, phylogenetics, speciation, and systematics. It has been designed as a companion to Glossary of cellular and molecular biology, which contains many overlapping and related terms; other related glossaries include Glossary of biology and Glossary of ecology.
In evolutionary biology, developmental bias refers to the production against or towards certain ontogenetic trajectories which ultimately influence the direction and outcome of evolutionary change by affecting the rates, magnitudes, directions and limits of trait evolution. Historically, the term was synonymous with developmental constraint, however, the latter has been more recently interpreted as referring solely to the negative role of development in evolution.
A selection gradient describes the relationship between a character trait and a species' relative fitness. A trait may be a physical characteristic, such as height or eye color, or behavioral, such as flying or vocalizing. Changes in a trait, such as the amount of seeds a plant produces or the length of a bird's beak, may improve or reduce their relative fitness. Changes in traits may accumulate in a population under an ongoing process of natural selection. Understanding how changes in a trait affect fitness helps evolutionary biologists understand the nature of evolutionary pressures on a population.