Syndecan-3

SDC3
Identifiers
Aliases	SDC3 , SDCN, SYND3, syndecan 3
External IDs	OMIM: 186357 MGI: 1349163 HomoloGene: 7965 GeneCards: SDC3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	30,908,758 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	130,553,630 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; amygdala; ; caudate nucleus; ; hypothalamus; ; putamen; ; left uterine tube; ; ganglionic eminence; ; prefrontal cortex; ; external globus pallidus; ; ventral tegmental area;
	Top expressed in
	calvaria; ; adrenal gland; ; molar; ; body of femur; ; visual cortex; ; olfactory epithelium; ; sciatic nerve; ; cerebellar cortex; ; pontine nuclei; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; identical protein binding ;
Cellular component	integral component of membrane ; membrane ; plasma membrane ; lysosomal lumen ; Golgi lumen ; cell surface ; extracellular matrix ; collagen-containing extracellular matrix ; microspike ;
Biological process	glycosaminoglycan metabolic process ; retinoid metabolic process ; glycosaminoglycan catabolic process ; glycosaminoglycan biosynthetic process ; leukocyte migration ; cell migration ;
	Sources:Amigo / QuickGO
Orthologs
	9672
	20970
	ENSG00000162512
	ENSMUSG00000025743
	O75056
	Q64519
	NM_014654
	NM_011520
	NP_055469
	NP_035650
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 24, 2023

Syndecan-3 is a protein that in humans is encoded by the SDC3 gene.^[5]^[6]^[7]

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Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. In this form, HS binds to a variety of protein ligands, including Wnt, and regulates a wide range of biological activities, including developmental processes, angiogenesis, blood coagulation, abolishing detachment activity by GrB, and tumour metastasis. HS has also been shown to serve as cellular receptor for a number of viruses, including the respiratory syncytial virus. One study suggests that cellular heparan sulfate has a role in SARS-CoV-2 Infection, particularly when the virus attaches with ACE2.

Midkine, also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene.

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. TGFBR3 is the most widely expressed type of TGF-beta receptor. Its affinity towards all individual isoforms of TGF-beta is similarly high and therefore it plays an important role as a coreceptor mediating the binding of TGF-beta to its other receptors - specifically TGFBR2. The intrinsic kinase activity of this receptor has not yet been described. In regard of TGF-beta signalling it is generally considered a non-signaling receptor or a coreceptor. By binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of TGF-beta.

Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein is a transmembrane heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Syndecan-1 is a sponge for growth factors and chemokines, with binding largely via heparan sulfate chains. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein.

Syndecans are single transmembrane domain proteins that are thought to act as coreceptors, especially for G protein-coupled receptors. More specifically, these core proteins carry three to five heparan sulfate and chondroitin sulfate chains, i.e. they are proteoglycans, which allow for interaction with a large variety of ligands including fibroblast growth factors, vascular endothelial growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Interactions between fibronectin and some syndecans can be modulated by the extracellular matrix protein tenascin C.

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene.

Syndecan-2 is a protein that in humans is encoded by the SDC2 gene.

Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. Also, syndecans bind to FGFs and bring them to the FGF receptor on the same cell. As a co-receptor or regulator, mutated certain proteoglycans could cause severe developmental defects, like disordered distribution or inactivation of signaling molecules.

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Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene.

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Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

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Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.

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<span class="mw-page-title-main">Carbohydrate sulfotransferase</span> Class of enzymes which transfer an –SO3 group to glycoproteins and lipids

In biochemistry, carbohydrate sulfotransferases are enzymes within the class of sulfotransferases which catalyze the transfer of the sulfate functional group to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162512 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025743 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Carey DJ, Evans DM, Stahl RC, Asundi VK, Conner KJ, Garbes P, Cizmeci-Smith G (May 1992). "Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan". J Cell Biol. 117 (1): 191–201. doi:10.1083/jcb.117.1.191. PMC 2289399 . PMID 1556152.
↑ Berndt C, Casaroli-Marano RP, Vilaro S, Reina M (Aug 2001). "Cloning and characterization of human syndecan-3". J Cell Biochem. 82 (2): 246–59. doi:10.1002/jcb.1119. PMID 11527150. S2CID 1870905.
↑ "Entrez Gene: SDC3 syndecan 3".

Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. Bibcode:1993PNAS...90.7941B. doi: 10.1073/pnas.90.17.7941 . PMC 47263 . PMID 7690138.
Raulo E, Chernousov MA, Carey DJ, et al. (1994). "Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)". J. Biol. Chem. 269 (17): 12999–3004. doi: 10.1016/S0021-9258(18)99975-8 . PMID 8175719.
Chernousov MA, Carey DJ (1993). "N-syndecan (syndecan 3) from neonatal rat brain binds basic fibroblast growth factor". J. Biol. Chem. 268 (22): 16810–4. doi: 10.1016/S0021-9258(19)85488-1 . PMID 8344959.
Albini A, Benelli R, Presta M, et al. (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289–97. PMID 8570206.
Chernousov MA, Stahl RC, Carey DJ (1996). "Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan". J. Biol. Chem. 271 (23): 13844–53. doi: 10.1074/jbc.271.23.13844 . PMID 8662884.
Nakanishi T, Kadomatsu K, Okamoto T, et al. (1997). "Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine". J. Biochem. 121 (2): 197–205. PMID 9089390.
Rusnati M, Coltrini D, Oreste P, et al. (1997). "Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size". J. Biol. Chem. 272 (17): 11313–20. doi: 10.1074/jbc.272.17.11313 . PMID 9111037.
Chang HC, Samaniego F, Nair BC, et al. (1997). "HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region". AIDS. 11 (12): 1421–31. doi: 10.1097/00002030-199712000-00006 . PMID 9342064. S2CID 7648619.
Asundi VK, Carey DJ (1997). "Phosphorylation of recombinant N-syndecan (syndecan 3) core protein". Biochem. Biophys. Res. Commun. 240 (2): 502–6. doi:10.1006/bbrc.1997.7684. PMID 9388509.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID 9455484.
Kinnunen T, Kaksonen M, Saarinen J, et al. (1998). "Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". J. Biol. Chem. 273 (17): 10702–8. doi: 10.1074/jbc.273.17.10702 . PMID 9553134.
Hsueh YP, Sheng M (1999). "Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development". J. Neurosci. 19 (17): 7415–25. doi: 10.1523/JNEUROSCI.19-17-07415.1999 . PMC 6782500 . PMID 10460248.
Rusnati M, Tulipano G, Spillmann D, et al. (1999). "Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides". J. Biol. Chem. 274 (40): 28198–205. doi: 10.1074/jbc.274.40.28198 . PMID 10497173.
Tyagi M, Rusnati M, Presta M, Giacca M (2001). "Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans". J. Biol. Chem. 276 (5): 3254–61. doi: 10.1074/jbc.M006701200 . PMID 11024024.
Koroll M, Rathjen FG, Volkmer H (2001). "The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity". J. Biol. Chem. 276 (14): 10646–54. doi: 10.1074/jbc.M010647200 . PMID 11152476.
Hakansson S, Jacobs A, Caffrey M (2001). "Heparin binding by the HIV-1 tat protein transduction domain". Protein Sci. 10 (10): 2138–9. doi:10.1110/ps.23401. PMC 2374215 . PMID 11567105.
Erdman R, Stahl RC, Rothblum K, et al. (2002). "Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3". J. Biol. Chem. 277 (9): 7619–25. doi: 10.1074/jbc.M111311200 . PMID 11751872.
Alvarez K, Fadic R, Brandan E (2002). "Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy". J. Cell. Biochem. 85 (4): 703–13. doi:10.1002/jcb.10184. hdl: 10533/173369 . PMID 11968010. S2CID 20243469.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162512 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025743 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1556152-5] Carey DJ, Evans DM, Stahl RC, Asundi VK, Conner KJ, Garbes P, Cizmeci-Smith G (May 1992). "Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan". J Cell Biol. 117 (1): 191–201. doi:10.1083/jcb.117.1.191. PMC 2289399 . PMID 1556152.

[pmid11527150-6] Berndt C, Casaroli-Marano RP, Vilaro S, Reina M (Aug 2001). "Cloning and characterization of human syndecan-3". J Cell Biochem. 82 (2): 246–59. doi:10.1002/jcb.1119. PMID 11527150. S2CID 1870905.

[entrez-7] "Entrez Gene: SDC3 syndecan 3".

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Syndecan-3

Related Research Articles

References

Further reading