Syntaphilin

SNPH
Identifiers
Aliases	SNPH , bA314N13.5, syntaphilin
External IDs	OMIM: 604942 MGI: 2139270 HomoloGene: 8817 GeneCards: SNPH
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,309,328 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	151,632,593 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; Brodmann area 46; ; postcentral gyrus; ; orbitofrontal cortex; ; entorhinal cortex; ; superior frontal gyrus; ; inferior olivary nucleus; ; cingulate gyrus; ; dorsolateral prefrontal cortex; ; amygdala;
	Top expressed in
	visual cortex; ; superior frontal gyrus; ; subiculum; ; hippocampus proper; ; prefrontal cortex; ; cingulate gyrus; ; olfactory tubercle; ; primary motor cortex; ; cerebellar cortex; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	syntaxin-1 binding ;
Cellular component	cytoplasm ; integral component of membrane ; neuron projection ; cytoplasmic microtubule ; cell junction ; neuronal cell body ; plasma membrane ; synapse ; presynaptic membrane ; mitochondrial membrane ; membrane ;
Biological process	brain development ; synaptic vesicle docking ; neurotransmitter secretion ; neuron differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	9751
	241727
	ENSG00000101298
	ENSMUSG00000027457
	O15079
	Q80U23
	NM_014723 ; NM_001318234
	NM_001291076 ; NM_001291077 ; NM_198214
	NP_001305163 ; NP_055538
	NP_001278005 ; NP_001278006 ; NP_937857
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Syntaphilin is a protein that in humans is encoded by the SNPH gene. ^[5]

Function

Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms.

Related Research Articles

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Syntaxin-12 is a protein that in humans is encoded by the STX12 gene.

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.

Protein kinase C and casein kinase substrate in neurons protein 1 is an enzyme that in humans is encoded by the PACSIN1 gene.

BET1-like protein is a protein that in humans is encoded by the BET1L gene.

Syntaxin-16 is a protein that in humans is encoded by the STX16 gene.

Syntaxin-binding protein 5 is a protein that in humans is encoded by the STXBP5 gene. It is also known as tomosyn, after 友, "friend" in Japanese, for its role as a binding protein.

Syntaxin-1B is a protein that in humans is encoded by the STX1B gene.

Vesicle transport through interaction with t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene.

RAS-like, estrogen-regulated, growth inhibitor is a protein in humans that is encoded by the RERG gene.

Calpain-6 is a protein in humans that is encoded by the CAPN6 gene.

Inositol monophosphatase 3 also known as inositol monophosphatase domain-containing protein 1 (IMPAD1) is an enzyme that in humans is encoded by the IMPAD1 gene.

Syntaxin 17 is a protein that in humans is encoded by the STX17 gene. In horses a duplication in intron 6 causes progressive graying.

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.

Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene.

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein.

Actin related protein 2/3 complex inhibitor is a protein that in humans is encoded by the ARPIN gene.

Forkhead box S1 is a protein that in humans is encoded by the FOXS1 gene.

Peptidase inhibitor 15 is a protein that in humans is encoded by the PI15 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101298 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027457 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Syntaphilin" . Retrieved 2016-11-01.

Syntaphilin

Contents

Function

Related Research Articles

References

Further reading