TAC3

TAC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P9F
Identifiers
Aliases	TAC3 , HH10, NKB, NKNB, PRO1155, ZNEUROK1, tachykinin 3, tachykinin precursor 3, NK3, LncZBTB39
External IDs	OMIM: 162330; MGI: 98476; HomoloGene: 7560; GeneCards: TAC3; OMA:TAC3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.3 Start 57,010,000 bp [1] End 57,028,883 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D3 Start 127,560,347 bp [2] End 127,567,637 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua gonad anterior cingulate cortex caudate nucleus prefrontal cortex nucleus accumbens dorsolateral prefrontal cortex right frontal lobe putamen testicle Top expressed in gastrula habenula lumbar subsegment of spinal cord lateral hypothalamus zygote neural layer of retina arcuate nucleus nucleus of stria terminalis secondary oocyte embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding protein binding neuromedin K receptor binding substance K receptor binding Cellular component extracellular region extracellular space Biological process female pregnancy neuropeptide signaling pathway tachykinin receptor signaling pathway positive regulation of flagellated sperm motility G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6866 21334 Ensembl ENSG00000166863 ENSMUSG00000025400 UniProt Q9UHF0 P55099 RefSeq (mRNA) NM_001006667 NM_001178054 NM_013251 NM_001199971 NM_009312 RefSeq (protein) NP_001171525 NP_037383 NP_001186900 NP_033338 Location (UCSC) Chr 12: 57.01 – 57.03 Mb Chr 10: 127.56 – 127.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tachykinin-3 is a protein that in humans is encoded by the TAC3 gene. ^{[5] [6] [7]}

See also

• Neurokinin B
• Tachykinin receptor 3

References

1. GRCh38: Ensembl release 89: ENSG00000166863 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025400 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bonner TI, Affolter HU, Young AC, Young WS (Jan 1988). "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B". Brain Res. 388 (3): 243–9. doi:10.1016/0169-328x(87)90031-3. PMID   3479225.
6. Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ (Jul 2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia". Nature. 405 (6788): 797–800. Bibcode:2000Natur.405..797P. doi:10.1038/35015579. PMID   10866201. S2CID   4392048.
7. "Entrez Gene: TAC3 tachykinin 3 (neuromedin K, neurokinin beta)".

Further reading

• Page NM, Woods RJ, Lowry PJ (2001). "A regulatory role for neurokinin B in placental physiology and pre-eclampsia". Regul. Pept. 98 (3): 97–104. doi:10.1016/S0167-0115(00)00239-1. PMID   11231038. S2CID   7160887.
• Rance NE, Young WS (1991). "Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women". Endocrinology. 128 (5): 2239–47. doi:10.1210/endo-128-5-2239. PMID   1708331.
• Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. Chem. 269 (44): 27269–74. doi: 10.1016/S0021-9258(18)46979-7 . PMID   7961636.
• Tian Y, Wu LH, Oxender DL, Chung FZ (1996). "The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity". J. Biol. Chem. 271 (34): 20250–7. doi: 10.1074/jbc.271.34.20250 . PMID   8702757.
• Krause JE, Staveteig PT, Mentzer JN, et al. (1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds 3Hsenktide and 125I-MePhe7neurokinin B, and is responsive to tachykinin peptide agonists". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 310–5. doi: 10.1073/pnas.94.1.310 . PMC   19326 . PMID   8990205.
• Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis". Neuropeptides. 32 (3): 215–23. doi:10.1016/S0143-4179(98)90040-3. PMID   10189055. S2CID   40222022.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brownbill P, Bell NJ, Woods RJ, et al. (2003). "Neurokinin B is a paracrine vasodilator in the human fetal placental circulation". J. Clin. Endocrinol. Metab. 88 (5): 2164–70. doi: 10.1210/jc.2002-021727 . PMID   12727971.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Schlembach D, Scalera F, Fischer T, et al. (2003). "Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women". Am. J. Obstet. Gynecol. 189 (5): 1418–22. doi:10.1067/S0002-9378(03)00775-0. PMID   14634580.
• Laliberte C, DiMarzo L, Morrish DW, Kaufman S (2004). "Neurokinin B causes concentration-dependent relaxation of isolated human placental resistance vessels". Regul. Pept. 117 (2): 123–6. doi:10.1016/j.regpep.2003.10.032. PMID   14700748. S2CID   25577867.
• Pal S, Nemeth MJ, Bodine D, et al. (2004). "Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1". J. Biol. Chem. 279 (30): 31348–56. doi: 10.1074/jbc.M403475200 . PMID   15123623.
• Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM (2005). "Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles". J. Biomol. Struct. Dyn. 22 (2): 137–48. doi:10.1080/07391102.2004.10506990. PMID   15317475. S2CID   41064499.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Page NM, Dakour J, Morrish DW (2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia". Mol. Hum. Reprod. 12 (7): 427–33. doi: 10.1093/molehr/gal025 . PMID   16709596.