TACC3

TACC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LPZ, 4PKY
Identifiers
Aliases	TACC3 , ERIC-1, ERIC1, transforming acidic coiled-coil containing protein 3, Tacc4, maskin
External IDs	OMIM: 605303; MGI: 1341163; HomoloGene: 81618; GeneCards: TACC3; OMA:TACC3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p16.3 Start 1,712,858 bp [1] End 1,745,171 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B2 Start 33,658,128 bp [2] End 33,678,995 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte ventricular zone secondary oocyte right testis left testis granulocyte monocyte blood ganglionic eminence gonad Top expressed in primary oocyte ventricular zone yolk sac epiblast tail of embryo primitive streak spermatocyte genital tubercle maxillary prominence embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule cytoskeleton spindle pole spindle cytoskeleton microtubule organizing center cytosol mitotic spindle Biological process cell population proliferation cerebral cortex development metaphase regulation of mitotic spindle organization microtubule cytoskeleton organization involved in mitosis cell cycle cell division microtubule cytoskeleton organization mitotic spindle organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10460 21335 Ensembl ENSG00000013810 ENSMUSG00000037313 UniProt Q9Y6A5 Q9JJ11 RefSeq (mRNA) NM_006342 NM_001040435 NM_011524 NM_001310541 RefSeq (protein) NP_006333 n/a Location (UCSC) Chr 4: 1.71 – 1.75 Mb Chr 5: 33.66 – 33.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transforming acidic coiled-coil-containing protein 3 is a protein that in humans is encoded by the TACC3 gene. ^{[5] [6]}

The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000013810 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037313 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nurnberg B, Piekorz RP (Oct 2007). "The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival". J Biol Chem. 282 (40): 29273–83. doi: 10.1074/jbc.M704151200 . PMID   17675670.
6. "Entrez Gene: TACC3 transforming, acidic coiled-coil containing protein 3".

Further reading

• Lappin TR, Mullan RN, Stewart JP, et al. (2003). "AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains". Leuk. Lymphoma. 43 (7): 1455–9. doi:10.1080/1042819022386644. PMID   12389629. S2CID   2098614.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID   10366448.
• Gergely F, Karlsson C, Still I, et al. (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi: 10.1073/pnas.97.26.14352 . PMC   18922 . PMID   11121038.
• McKeveney PJ, Hodges VM, Mullan RN, et al. (2001). "Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells". Br. J. Haematol. 112 (4): 1016–24. doi:10.1046/j.1365-2141.2001.02644.x. PMID   11298601. S2CID   27869385.
• Piekorz RP, Hoffmeyer A, Duntsch CD, et al. (2002). "The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis". EMBO J. 21 (4): 653–64. doi:10.1093/emboj/21.4.653. PMC   125348 . PMID   11847113.
• Steadman BT, Schmidt PH, Shanks RA, et al. (2002). "Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus". J. Biol. Chem. 277 (33): 30165–76. doi: 10.1074/jbc.M201914200 . PMID   12015314.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sadek CM, Pelto-Huikko M, Tujague M, et al. (2004). "TACC3 expression is tightly regulated during early differentiation". Gene Expr. Patterns. 3 (2): 203–11. doi:10.1016/S1567-133X(02)00066-2. PMID   12711550.
• Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. CiteSeerX   10.1.1.539.8359 . doi:10.1016/S0006-291X(03)01486-4. PMID   12927788.
• Gangisetty O, Lauffart B, Sondarva GV, et al. (2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene. 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID   14767476. S2CID   22590391.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.