TAF1B

TAF1B
Identifiers
Aliases	TAF1B , MGC:9349, RAF1B, RAFI63, SL1, TAFI63, TATA-box binding protein associated factor, RNA polymerase I subunit B
External IDs	OMIM: 604904; MGI: 109577; HomoloGene: 31331; GeneCards: TAF1B; OMA:TAF1B - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p25.1 Start 9,843,443 bp [1] End 9,934,416 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 A1.3 Start 24,548,358 bp [2] End 24,608,538 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad Achilles tendon buccal mucosa cell ventricular zone monocyte islet of Langerhans stromal cell of endometrium secondary oocyte olfactory zone of nasal mucosa Top expressed in spermatocyte zygote secondary oocyte seminiferous tubule yolk sac tail of embryo dentate gyrus of hippocampal formation granule cell morula morula genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity metal ion binding protein binding TBP-class protein binding RNA polymerase I core promoter sequence-specific DNA binding Cellular component nucleoplasm RNA polymerase transcription factor SL1 complex nucleolus nucleus RNA polymerase I core factor complex Biological process termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation regulation of transcription, DNA-templated transcription initiation from RNA polymerase I promoter transcription, DNA-templated transcription by RNA polymerase I RNA polymerase I preinitiation complex assembly nucleolar large rRNA transcription by RNA polymerase I transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9014 21340 Ensembl ENSG00000115750 ENSMUSG00000059669 UniProt Q53T94 P97358 RefSeq (mRNA) NM_005680 NM_001318976 NM_001318977 NM_020614 RefSeq (protein) NP_001305905 NP_001305906 NP_005671 NP_065639 Location (UCSC) Chr 2: 9.84 – 9.93 Mb Chr 12: 24.55 – 24.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene. ^{[5] [6]}

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. ^[6]

Interactions

TAF1B has been shown to interact with RRN3. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000115750 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059669 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (January 1995). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. Bibcode:1994Sci...266.1966C. doi:10.1126/science.7801123. PMID   7801123.
6. "Entrez Gene: TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa".
7. Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (March 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC   145519 . PMID   11250903.

Further reading

• Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID   10894955. S2CID   27014629.
• Zhai W, Comai L (2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC   86070 . PMID   10913176.
• Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC   145519 . PMID   11250903.
• Kim NG, Rhee H, Li LS, Kim H, Lee JS, Kim JH, Kim NK, Kim H (2002). "Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability". Oncogene. 21 (33): 5081–7. doi: 10.1038/sj.onc.1205703 . PMID   12140758.
• Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC   1307603 . PMID   12393749.
• Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID   15723054. S2CID   8913931.
• You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H (2007). "Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors". PLOS Biol. 5 (5): e109. doi: 10.1371/journal.pbio.0050109 . PMC   1854916 . PMID   17456004.