TAF3

TAF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5C13
Identifiers
Aliases	TAF3 , TAF140, TAFII-140, TAFII140, TATA-box binding protein associated factor 3
External IDs	OMIM: 606576; MGI: 2388097; HomoloGene: 35415; GeneCards: TAF3; OMA:TAF3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10p14 Start 7,818,497 bp [1] End 8,016,631 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A1 Start 9,919,363 bp [2] End 10,053,407 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii vena cava oocyte cardia sural nerve secondary oocyte internal globus pallidus pylorus pericardium ventral tegmental area Top expressed in zygote primary oocyte secondary oocyte genital tubercle otolith organ utricle tail of embryo substantia nigra hand retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function p53 binding protein binding metal ion binding protein heterodimerization activity Cellular component nucleus nucleoplasm nuclear membrane transcription factor TFIID complex Biological process transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of DNA-binding transcription factor activity maintenance of protein location in nucleus transcription, DNA-templated regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83860 209361 Ensembl ENSG00000165632 ENSMUSG00000025782 UniProt Q5VWG9 Q5HZG4 RefSeq (mRNA) NM_031923 NM_027748 RefSeq (protein) NP_114129 NP_082024 Location (UCSC) Chr 10: 7.82 – 8.02 Mb Chr 2: 9.92 – 10.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation factor TFIID subunit 3 is a protein that in humans is encoded by the TAF3 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000165632 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025782 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gangloff YG, Pointud JC, Thuault S, Carre L, Romier C, Muratoglu S, Brand M, Tora L, Couderc JL, Davidson I (Jul 2001). "The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger". Mol Cell Biol. 21 (15): 5109–21. doi:10.1128/MCB.21.15.5109-5121.2001. PMC   87236 . PMID   11438666.
6. Bereczki O, Ujfaludi Z, Pardi N, Nagy Z, Tora L, Boros IM, Balint E (Jun 2008). "TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function". BMC Mol Biol. 9: 57. doi: 10.1186/1471-2199-9-57 . PMC   2441632 . PMID   18549481.
7. "Entrez Gene: TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Soutoglou E, Demény MA, Scheer E, et al. (2005). "The Nuclear Import of TAF10 Is Regulated by One of Its Three Histone Fold Domain-Containing Interaction Partners". Mol. Cell. Biol. 25 (10): 4092–104. doi:10.1128/MCB.25.10.4092-4104.2005. PMC   1087738 . PMID   15870280.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.