TAF4B

TAF4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H3O, 2P6V
Identifiers
Aliases	TAF4B , SPGF13, TAF2C2, TAFII105, TATA-box binding protein associated factor 4b
External IDs	OMIM: 601689; MGI: 2152345; HomoloGene: 28266; GeneCards: TAF4B; OMA:TAF4B - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q11.2 Start 26,226,445 bp [1] End 26,391,685 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 A1 Start 14,916,302 bp [2] End 15,033,416 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell gonad testicle Brodmann area 23 endothelial cell middle temporal gyrus cartilage tissue Achilles tendon tibialis anterior muscle Top expressed in Epithelium of choroid plexus lumbar spinal ganglion hand Gonadal ridge otolith organ utricle Paneth cell cumulus cell oocyte secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding NF-kappaB binding protein heterodimerization activity transcription coactivator activity transcription factor binding RNA polymerase II general transcription initiation factor activity Cellular component cytoplasm nucleus nucleoplasm fibrillar center transcription factor TFIID complex Biological process DNA-templated transcription, initiation cell differentiation transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II spermatogenesis transcription, DNA-templated oogenesis regulation of signal transduction by p53 class mediator positive regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6875 72504 Ensembl ENSG00000141384 ENSMUSG00000054321 UniProt Q92750 G5E8Z2 RefSeq (mRNA) NM_001293725 NM_005640 NM_001100449 NM_001369357 NM_001369358 RefSeq (protein) NP_001280654 NP_005631 NP_001093919 NP_001356286 NP_001356287 Location (UCSC) Chr 18: 26.23 – 26.39 Mb Chr 18: 14.92 – 15.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene. ^{[5] [6] [7]}

Function

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM] ^[7]

Interactions

TAF4B has been shown to interact with RELA. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000141384 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054321 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell. 87 (1): 137–46. doi: 10.1016/S0092-8674(00)81330-6 . PMID   8858156. S2CID   10194253.
6. Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi: 10.1074/jbc.275.24.18180 . PMID   10849440.
7. "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".
8. Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC   1170844 . PMID   9724652.

Further reading

• Liu WL, Coleman RA, Grob P, King DS, Florens L, Washburn MP, Geles KG, Yang JL, Ramey V, Nogales E, Tjian R (2008). "Structural changes in TAF4b-TFIID correlate with promoter selectivity". Mol. Cell. 29 (1): 81–91. doi:10.1016/j.molcel.2007.11.003. PMC   2486835 . PMID   18206971.
• Wu Y, Lu Y, Hu Y, Li R (2005). "Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line". J. Cell. Biochem. 96 (4): 751–9. doi:10.1002/jcb.20577. PMID   16088961. S2CID   23658728.
• Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R (2005). "Core promoter binding by histone-like TAF complexes". Mol. Cell. Biol. 25 (1): 206–19. doi:10.1128/MCB.25.1.206-219.2005. PMC   538770 . PMID   15601843.
• Rashevsky-Finkel A, Silkov A, Dikstein R (2001). "A composite nuclear export signal in the TBP-associated factor TAFII105". J. Biol. Chem. 276 (48): 44963–9. doi: 10.1074/jbc.M106112200 . PMID   11567023.
• Wolstein O, Silkov A, Revach M, Dikstein R (2000). "Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription". J. Biol. Chem. 275 (22): 16459–65. doi: 10.1074/jbc.275.22.16459 . PMID   10828057.
• Yamit-Hezi A, Dikstein R (1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC   1170844 . PMID   9724652.