TAF4B

Last updated
TAF4B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAF4B , SPGF13, TAF2C2, TAFII105, TATA-box binding protein associated factor 4b
External IDs OMIM: 601689 MGI: 2152345 HomoloGene: 28266 GeneCards: TAF4B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001293725
NM_005640

NM_001100449
NM_001369357
NM_001369358

RefSeq (protein)

NP_001280654
NP_005631

NP_001093919
NP_001356286
NP_001356287

Location (UCSC) Chr 18: 26.23 – 26.39 Mb Chr 18: 14.92 – 15.03 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene. [5] [6] [7]

Contents

Function

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM] [7]

Interactions

TAF4B has been shown to interact with RELA. [8]

Related Research Articles

<span class="mw-page-title-main">TATA-binding protein</span> Protein-coding gene in the species Homo sapiens

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

Transcription factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists of RNA polymerase II, a subset of general transcription factors, and regulatory proteins known as SRB proteins. Before the start of transcription, the transcription Factor II D (TFIID) complex binds to the core promoter DNA of the gene through specific recognition of promoter sequence motifs, including the TATA box, Initiator, Downstream Promoter, Motif Ten, or Downstream Regulatory elements.

<span class="mw-page-title-main">TAF6</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.

<span class="mw-page-title-main">TAF7</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.

<span class="mw-page-title-main">TAF1</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa (p250), is a protein that in humans is encoded by the TAF1 gene.

<span class="mw-page-title-main">TAF9</span> Protein-coding gene in the species Homo sapiens

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in humans is encoded by the TAF9 gene.

<span class="mw-page-title-main">TAF12</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.

<span class="mw-page-title-main">TAF4</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.

<span class="mw-page-title-main">TAF2</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

<span class="mw-page-title-main">TAF10</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the TAF10 gene.

<span class="mw-page-title-main">TAF5</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.

<span class="mw-page-title-main">TAF11</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 gene.

<span class="mw-page-title-main">TAF15</span> Protein-coding gene in the species Homo sapiens

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.

<span class="mw-page-title-main">BTAF1</span> Protein-coding gene in the species Homo sapiens

TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.

<span class="mw-page-title-main">TAF13</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 13 is a protein that in humans is encoded by the TAF13 gene.

<span class="mw-page-title-main">TAF8</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 8 is a protein that in humans is encoded by the TAF8 gene.

<span class="mw-page-title-main">TAF1A</span> Protein-coding gene in the species Homo sapiens

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.

<span class="mw-page-title-main">TAF1B</span> Protein-coding gene in the species Homo sapiens

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.

<span class="mw-page-title-main">TAF9B</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene.

<span class="mw-page-title-main">TBP-associated factor</span> Protein domains

The TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a part of the transcription initiation factor TFIID multimeric protein complex. It also makes up many other factors, including SL1. They mediate the formation of the transcription preinitiation complex, a step preceding transcription of DNA to RNA by RNA polymerase II.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000141384 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054321 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell. 87 (1): 137–46. doi: 10.1016/S0092-8674(00)81330-6 . PMID   8858156. S2CID   10194253.
  6. Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi: 10.1074/jbc.275.24.18180 . PMID   10849440.
  7. 1 2 "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".
  8. Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC   1170844 . PMID   9724652.

Further reading