TAGLN2

TAGLN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WYM
Identifiers
Aliases	TAGLN2 , HA1756, transgelin 2
External IDs	OMIM: 604634; MGI: 1312985; HomoloGene: 20789; GeneCards: TAGLN2; OMA:TAGLN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.2 Start 159,918,107 bp [1] End 159,925,507 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 79.89 cM Start 172,327,614 bp [2] End 172,334,947 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in upper lobe of left lung right lung monocyte granulocyte islet of Langerhans ventricular zone skin of abdomen mucosa of transverse colon minor salivary glands gallbladder Top expressed in pyloric antrum epithelium of stomach mucous cell of stomach lip tail of embryo right lung yolk sac right lung lobe esophagus left lung More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding cadherin binding Cellular component vesicle extracellular exosome extracellular region cytosol Biological process epithelial cell differentiation platelet degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8407 21346 Ensembl ENSG00000158710 ENSMUSG00000026547 UniProt P37802 Q9WVA4 RefSeq (mRNA) NM_003564 NM_001277223 NM_001277224 NM_178598 RefSeq (protein) NP_001264152 NP_001264153 NP_003555 NP_848713 Location (UCSC) Chr 1: 159.92 – 159.93 Mb Chr 1: 172.33 – 172.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transgelin-2 is a protein that in humans is encoded by the TAGLN2 gene. ^{[5] [6]}

The protein encoded by this gene is a homolog of the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The function of this protein has not yet been determined. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000158710 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026547 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stanier P, Abu-Hayyeh S, Murdoch JN, Eddleston J, Copp AJ (Sep 1998). "Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship". Genomics. 51 (1): 144–7. doi:10.1006/geno.1998.5381. PMID   9693045.
6. "Entrez Gene: TAGLN2 transgelin 2".

Further reading

• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID   7788527.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID   10942595.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID   16021519. S2CID   6644433.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.