TAGLN3

TAGLN3
Identifiers
Aliases	TAGLN3 , NP22, NP24, NP25, transgelin 3
External IDs	OMIM: 607953; MGI: 1926784; HomoloGene: 22337; GeneCards: TAGLN3; OMA:TAGLN3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.2 Start 111,998,739 bp [1] End 112,013,887 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B5 Start 45,531,593 bp [2] End 45,544,971 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole right frontal lobe Brodmann area 10 cerebellar hemisphere right hemisphere of cerebellum dorsolateral prefrontal cortex Brodmann area 9 ganglionic eminence cingulate gyrus anterior cingulate cortex Top expressed in dentate gyrus of hippocampal formation granule cell cerebellar cortex pontine nuclei lateral septal nucleus lobe of cerebellum cerebellar vermis medial vestibular nucleus ventromedial nucleus superior frontal gyrus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding Cellular component nucleus myelin sheath Biological process central nervous system development negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29114 56370 Ensembl ENSG00000144834 ENSMUSG00000022658 UniProt Q9UI15 Q9R1Q8 RefSeq (mRNA) NM_013259 NM_001008272 NM_001008273 NM_019754 RefSeq (protein) NP_001008273 NP_001008274 NP_037391 NP_062728 Location (UCSC) Chr 3: 112 – 112.01 Mb Chr 16: 45.53 – 45.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transgelin-3 or neuron protein NP25 is a protein that is in the nerve cells of humans, rats, mice, and chickens. It is encoded by the TAGLN3 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000144834 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022658 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ren WZ, Ng GY, Wang RX, Wu PH, O'Dowd BF, Osmond DH, George SR, Liew CC (Jul 1994). "The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations". Brain Res Mol Brain Res. 22 (1–4): 173–85. doi:10.1016/0169-328X(94)90045-0. PMID   8015377.
6. Fan L, Jaquet V, Dodd PR, Chen W, Wilce PA (Mar 2001). "Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain". J Neurochem. 76 (5): 1275–81. doi: 10.1046/j.1471-4159.2001.00176.x . PMID   11238712. S2CID   26310150.
7. "Entrez Gene: TAGLN3 transgelin 3".

Further reading

• Ito M, Depaz I, Wilce P, et al. (2005). "Expression of human neuronal protein 22, a novel cytoskeleton-associated protein, was decreased in the anterior cingulate cortex of schizophrenia". Neurosci. Lett. 378 (3): 125–30. doi:10.1016/j.neulet.2004.12.079. PMID   15781144. S2CID   10926640.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Depaz I, Ito M, Matsumoto I, et al. (2004). "Expression of hNP22 is altered in the frontal cortex and hippocampus of the alcoholic human brain" (PDF). Alcohol. Clin. Exp. Res. 27 (9): 1481–8. doi:10.1097/01.ALC.0000086060.18032.59. PMID   14506410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID   12107411.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.